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Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism

The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae...

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Autor principal: Bordel, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804853/
https://www.ncbi.nlm.nih.gov/pubmed/24145501
http://dx.doi.org/10.1038/srep03017
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author Bordel, Sergio
author_facet Bordel, Sergio
author_sort Bordel, Sergio
collection PubMed
description The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments.
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spelling pubmed-38048532013-10-22 Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism Bordel, Sergio Sci Rep Article The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments. Nature Publishing Group 2013-10-22 /pmc/articles/PMC3804853/ /pubmed/24145501 http://dx.doi.org/10.1038/srep03017 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Article
Bordel, Sergio
Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title_full Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title_fullStr Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title_full_unstemmed Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title_short Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
title_sort experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804853/
https://www.ncbi.nlm.nih.gov/pubmed/24145501
http://dx.doi.org/10.1038/srep03017
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