Cargando…
Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804853/ https://www.ncbi.nlm.nih.gov/pubmed/24145501 http://dx.doi.org/10.1038/srep03017 |
_version_ | 1782288221813604352 |
---|---|
author | Bordel, Sergio |
author_facet | Bordel, Sergio |
author_sort | Bordel, Sergio |
collection | PubMed |
description | The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments. |
format | Online Article Text |
id | pubmed-3804853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38048532013-10-22 Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism Bordel, Sergio Sci Rep Article The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments. Nature Publishing Group 2013-10-22 /pmc/articles/PMC3804853/ /pubmed/24145501 http://dx.doi.org/10.1038/srep03017 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Article Bordel, Sergio Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title | Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title_full | Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title_fullStr | Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title_full_unstemmed | Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title_short | Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
title_sort | experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804853/ https://www.ncbi.nlm.nih.gov/pubmed/24145501 http://dx.doi.org/10.1038/srep03017 |
work_keys_str_mv | AT bordelsergio experimentalevidencesuggeststheexistenceofevolutionaryconservedglobaloperationprinciplesgoverningmicrobialmetabolism |