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Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Cancer commonly occurs in the elderly and immunotherapy (IT) is being increasingly applied to this population. However, the majority of preclinical mouse tumor models assessing potential efficacy and toxicities of therapeutics use young mice. We assessed the impact of age on responses to systemic im...

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Detalles Bibliográficos
Autores principales:	Bouchlaka, Myriam N., Sckisel, Gail D., Chen, Mingyi, Mirsoian, Annie, Zamora, Anthony E., Maverakis, Emanual, Wilkins, Danice E.C., Alderson, Kory L., Hsiao, Hui-Hua, Weiss, Jonathan M., Monjazeb, Arta M., Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L., Blazar, Bruce R., Wiltrout, Robert H., Redelman, Doug, Taub, Dennis D., Murphy, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804937/ https://www.ncbi.nlm.nih.gov/pubmed/24081947 http://dx.doi.org/10.1084/jem.20131219

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