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Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance

Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics and a BCR-ABL model of CML, we observed cross talk between Wnt/β-catenin signaling and the interferon-regulatory factor 8 (Irf8). In normal hematop...

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Detalles Bibliográficos
Autores principales:	Scheller, Marina, Schönheit, Jörg, Zimmermann, Karin, Leser, Ulf, Rosenbauer, Frank, Leutz, Achim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804946/ https://www.ncbi.nlm.nih.gov/pubmed/24101380 http://dx.doi.org/10.1084/jem.20130706

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