Cargando…

Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target

The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine sulfhydrylase. In bacteria, two isozymes, O-acetylserine sulfhydrylase-A and O-acetylserine sulfhydrylase-B, have been identified that share similar binding sites, although the respective specific functions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spyrakis, Francesca, Singh, Ratna, Cozzini, Pietro, Campanini, Barbara, Salsi, Enea, Felici, Paolo, Raboni, Samanta, Benedetti, Paolo, Cruciani, Gabriele, Kellogg, Glen E., Cook, Paul F., Mozzarelli, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805590/ https://www.ncbi.nlm.nih.gov/pubmed/24167577 http://dx.doi.org/10.1371/journal.pone.0077558

Ejemplares similares

Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives
por: Franko, Nina, et al.
Publicado: (2018)

Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms
por: Magalhães, Joana, et al.
Publicado: (2018)

Impact of overexpression of cytosolic isoform of O-acetylserine sulfhydrylase on soybean nodulation and nodule metabolome
por: Krishnan, Hari B., et al.
Publicado: (2018)

Comparative thermodynamic studies on substrate and product binding of O-Acetylserine Sulfhydrylase reveals two different ligand recognition modes(†)
por: Banerjee, Shrijita, et al.
Publicado: (2011)

Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria
por: Annunziato, Giannamaria, et al.
Publicado: (2022)

Energetics of the protein-DNA-water interaction
por: Spyrakis, Francesca, et al.
Publicado: (2007)

K30, H150, and H168 Are Essential Residues for Coordinating Pyridoxal 5′-Phosphate of O-Acetylserine Sulfhydrylase from Acidithiobacillus ferrooxidans
por: Zheng, Chunli, et al.
Publicado: (2009)

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design
por: Magalhães, Joana, et al.
Publicado: (2018)

Bound Water at Protein-Protein Interfaces: Partners, Roles and Hydrophobic Bubbles as a Conserved Motif
por: Ahmed, Mostafa H., et al.
Publicado: (2011)

HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham
por: Kellogg, Glen E., et al.
Publicado: (2023)

ADIFAB fluorescence data used for the quantification of free fatty acids in media at different pH
por: Faggiano, Serena, et al.
Publicado: (2018)

The Energy Landscape of Human Serine Racemase
por: Raboni, Samanta, et al.
Publicado: (2019)

Identification and Characterization of an O-Succinyl-L-Homoserine Sulfhydrylase From Thioalkalivibrio sulfidiphilus
por: Zhu, Wen-Yuan, et al.
Publicado: (2021)

C. elegans Aging Is Modulated by Hydrogen Sulfide and the sulfhydrylase/cysteine Synthase cysl-2
por: Qabazard, Bedoor, et al.
Publicado: (2013)

From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field
por: Agosta, Federica, et al.
Publicado: (2022)

New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond
por: Apodiakou, Anastasia, et al.
Publicado: (2023)

Post-Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells
por: Montalbano, Serena, et al.
Publicado: (2023)

Investigation of β‐Substitution Activity of O‐Acetylserine Sulfhydrolase from Citrullus vulgaris
por: Smith, Jamorious L., et al.
Publicado: (2022)

Insight of Saffron Proteome by Gel-Electrophoresis
por: Paredi, Gianluca, et al.
Publicado: (2016)

Exploring Ligand Binding Domain Dynamics in the NRs Superfamily
por: D’Arrigo, Giulia, et al.
Publicado: (2022)

CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin
por: Gabba, Matteo, et al.
Publicado: (2013)

Editorial: Computational methods for protein characterization: in memoriam of Donald Abraham
por: Spyrakis, Francesca, et al.
Publicado: (2023)

Virtual Screening, Identification and In Vitro Testing of Novel Inhibitors of O-Acetyl-L-Serine Sulfhydrylase of Entamoeba histolytica
por: Nagpal, Isha, et al.
Publicado: (2012)

Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus
por: Ronda, Luca, et al.
Publicado: (2020)

Metabolism and Regulatory Functions of O-Acetylserine, S-Adenosylmethionine, Homocysteine, and Serine in Plant Development and Environmental Responses
por: Watanabe, Mutsumi, et al.
Publicado: (2021)

Natural Variation in OASC Gene for Mitochondrial O-Acetylserine Thiollyase Affects Sulfate Levels in Arabidopsis
por: Koprivova, Anna, et al.
Publicado: (2022)

A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine γ-Lyase
por: Raboni, Samanta, et al.
Publicado: (2021)

Affinity Purification of O-Acetylserine(thiol)lyase from Chlorella sorokiniana by Recombinant Proteins from Arabidopsis thaliana
por: Salbitani, Giovanna, et al.
Publicado: (2014)

Tylosin Inhibits Streptococcus suis Biofilm Formation by Interacting With the O-acetylserine (thiol)-lyase B CysM
por: Zhou, Yonghui, et al.
Publicado: (2022)

Mycotoxin Detection Plays “Cops and Robbers”: Cyclodextrin Chemosensors as Specialized Police?
por: Cozzini, Pietro, et al.
Publicado: (2008)

Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants
por: Magalhães, Joana, et al.
Publicado: (2021)

Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume
por: Tabe, Linda, et al.
Publicado: (2010)

A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis
por: Shirzadian-Khorramabad, Reza, et al.
Publicado: (2010)

Long-term modulation of mitochondrial Ca(2+) signals by protein kinase C isozymes
por: Pinton, Paolo, et al.
Publicado: (2004)

Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of the Enzyme
por: Singh, Raushan K., et al.
Publicado: (2014)

A spinach O-acetylserine(thiol)lyase homologue, SoCSaseLP, suppresses cysteine biosynthesis catalysed by other enzyme isoforms
por: Noda, Miki, et al.
Publicado: (2016)

Kynurenine Aminotransferase Isozyme Inhibitors: A Review
por: Nematollahi, Alireza, et al.
Publicado: (2016)

Characterizing Isozymes of Chlorite Dismutase for Water Treatment
por: Mobilia, Kellen C., et al.
Publicado: (2017)

The Role of DUOX Isozymes in the Respiratory Tract Epithelium
por: Harper, Richard
Publicado: (2008)

Hydrogen Sulfide-Mediated Activation of O-Acetylserine (Thiol) Lyase and l/d-Cysteine Desulfhydrase Enhance Dehydration Tolerance in Eruca sativa Mill
por: Khan, M. Nasir, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_li210g6gj49qvlfdfukkeotke1