KLF15 Is a Molecular Link between Endoplasmic Reticulum Stress and Insulin Resistance

Obesity places major demands on the protein folding capacity of the endoplasmic reticulum (ER), resulting in ER stress, a condition that promotes hepatic insulin resistance and steatosis. Here we identify the transcription factor, Kruppel-like factor 15 (KLF15), as an essential mediator of ER stress...

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Detalles Bibliográficos
Autores principales: Jung, Dae Young, Chalasani, UmaDevi, Pan, Ning, Friedline, Randall H., Prosdocimo, Domenick A., Nam, Minwoo, Azuma, Yoshihiro, Maganti, Rajanikanth, Yu, Kristine, Velagapudi, Ashish, O’Sullivan-Murphy, Bryan, Sartoretto, Juliano L., Jain, Mukesh K., Cooper, Marcus P., Urano, Fumihiko, Kim, Jason K., Gray, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805598/
https://www.ncbi.nlm.nih.gov/pubmed/24167585
http://dx.doi.org/10.1371/journal.pone.0077851

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