Novel function of STAT1 in breast cancer

In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs). Inhibiting STAT1 activity offe...

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Detalles Bibliográficos
Autor principal: Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805635/
https://www.ncbi.nlm.nih.gov/pubmed/24167758
http://dx.doi.org/10.4161/onci.25125
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author Zhang, Ming
author_facet Zhang, Ming
author_sort Zhang, Ming
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description In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs). Inhibiting STAT1 activity offers a promising therapeutic approach against advanced breast cancer.
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spelling pubmed-38056352013-10-28 Novel function of STAT1 in breast cancer Zhang, Ming Oncoimmunology Author's View In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs). Inhibiting STAT1 activity offers a promising therapeutic approach against advanced breast cancer. Landes Bioscience 2013-08-01 2013-05-28 /pmc/articles/PMC3805635/ /pubmed/24167758 http://dx.doi.org/10.4161/onci.25125 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Zhang, Ming
Novel function of STAT1 in breast cancer
title Novel function of STAT1 in breast cancer
title_full Novel function of STAT1 in breast cancer
title_fullStr Novel function of STAT1 in breast cancer
title_full_unstemmed Novel function of STAT1 in breast cancer
title_short Novel function of STAT1 in breast cancer
title_sort novel function of stat1 in breast cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805635/
https://www.ncbi.nlm.nih.gov/pubmed/24167758
http://dx.doi.org/10.4161/onci.25125
work_keys_str_mv AT zhangming novelfunctionofstat1inbreastcancer

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