The many flavors of tumor-associated B cells

Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neopla...

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Detalles Bibliográficos
Autores principales: Marits, Per, Zirakzadeh, Ali A, Sherif, Amir, Winqvist, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805648/
https://www.ncbi.nlm.nih.gov/pubmed/24167763
http://dx.doi.org/10.4161/onci.25237
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author Marits, Per
Zirakzadeh, Ali A
Sherif, Amir
Winqvist, Ola
author_facet Marits, Per
Zirakzadeh, Ali A
Sherif, Amir
Winqvist, Ola
author_sort Marits, Per
collection PubMed
description Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neoplastic lesions. Here we discuss the role of B lymphocytes as antigen-presenting cells and catalysts of T cell-based immunotherapies in view of these findings.
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spelling pubmed-38056482013-10-28 The many flavors of tumor-associated B cells Marits, Per Zirakzadeh, Ali A Sherif, Amir Winqvist, Ola Oncoimmunology Author's View Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neoplastic lesions. Here we discuss the role of B lymphocytes as antigen-presenting cells and catalysts of T cell-based immunotherapies in view of these findings. Landes Bioscience 2013-08-01 2013-06-10 /pmc/articles/PMC3805648/ /pubmed/24167763 http://dx.doi.org/10.4161/onci.25237 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Marits, Per
Zirakzadeh, Ali A
Sherif, Amir
Winqvist, Ola
The many flavors of tumor-associated B cells
title The many flavors of tumor-associated B cells
title_full The many flavors of tumor-associated B cells
title_fullStr The many flavors of tumor-associated B cells
title_full_unstemmed The many flavors of tumor-associated B cells
title_short The many flavors of tumor-associated B cells
title_sort many flavors of tumor-associated b cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805648/
https://www.ncbi.nlm.nih.gov/pubmed/24167763
http://dx.doi.org/10.4161/onci.25237
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