Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lympho...

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Autores principales: Koido, Shigeo, Homma, Sadamu, Okamoto, Masato, Namiki, Yoshihisa, Kan, Shin, Takakura, Kazuki, Kajihara, Mikio, Uchiyama, Kan, Hara, Eiich, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805650/
https://www.ncbi.nlm.nih.gov/pubmed/24167764
http://dx.doi.org/10.4161/onci.25375
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author Koido, Shigeo
Homma, Sadamu
Okamoto, Masato
Namiki, Yoshihisa
Kan, Shin
Takakura, Kazuki
Kajihara, Mikio
Uchiyama, Kan
Hara, Eiich
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
author_facet Koido, Shigeo
Homma, Sadamu
Okamoto, Masato
Namiki, Yoshihisa
Kan, Shin
Takakura, Kazuki
Kajihara, Mikio
Uchiyama, Kan
Hara, Eiich
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
author_sort Koido, Shigeo
collection PubMed
description Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFβ1 blockade and the production of interleukin-12.
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spelling pubmed-38056502013-10-28 Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation Koido, Shigeo Homma, Sadamu Okamoto, Masato Namiki, Yoshihisa Kan, Shin Takakura, Kazuki Kajihara, Mikio Uchiyama, Kan Hara, Eiich Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao Oncoimmunology Author's View Tumor-derived transforming growth factor β1 (TGFβ1) generally abrogates the immunogenicity of dendritic cells (DCs) fused to whole cancer cells. We have recently revealed that ethanol-treated neoplastic cells fused to DCs exposed to 2 Toll-like receptor agonists efficiently induce cytotoxic T lymphocytes via TGFβ1 blockade and the production of interleukin-12. Landes Bioscience 2013-08-01 2013-07-01 /pmc/articles/PMC3805650/ /pubmed/24167764 http://dx.doi.org/10.4161/onci.25375 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Koido, Shigeo
Homma, Sadamu
Okamoto, Masato
Namiki, Yoshihisa
Kan, Shin
Takakura, Kazuki
Kajihara, Mikio
Uchiyama, Kan
Hara, Eiich
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title_full Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title_fullStr Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title_full_unstemmed Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title_short Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
title_sort improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual tlr stimulation
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805650/
https://www.ncbi.nlm.nih.gov/pubmed/24167764
http://dx.doi.org/10.4161/onci.25375
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