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The roles of ARID1A in gynecologic cancer

One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberr...

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Autores principales: Mao, Tsui-Lien, Shih, Ie-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805919/
https://www.ncbi.nlm.nih.gov/pubmed/24167674
http://dx.doi.org/10.3802/jgo.2013.24.4.376
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author Mao, Tsui-Lien
Shih, Ie-Ming
author_facet Mao, Tsui-Lien
Shih, Ie-Ming
author_sort Mao, Tsui-Lien
collection PubMed
description One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is because chromatin remodeling influences a variety of DNA activities such as replication, transcription, repair, methylation, and recombination. Among the mutated chromatin remodeling genes reported, ARID1A is frequently mutated in a variety of human cancers, especially in endometrium-related neoplasms including ovarian clear cell carcinoma, ovarian endometrioid carcinomas, and uterine endometrioid carcinomas, all of which arise from endometrial epithelium. This review will summarize the recent advances in studying the roles of ARID1A mutations in gynecologic cancers with special emphasis on how this new knowledge will further extend our understanding of the pathogenesis of endometrium-related carcinomas.
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spelling pubmed-38059192013-10-28 The roles of ARID1A in gynecologic cancer Mao, Tsui-Lien Shih, Ie-Ming J Gynecol Oncol Review Article One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is because chromatin remodeling influences a variety of DNA activities such as replication, transcription, repair, methylation, and recombination. Among the mutated chromatin remodeling genes reported, ARID1A is frequently mutated in a variety of human cancers, especially in endometrium-related neoplasms including ovarian clear cell carcinoma, ovarian endometrioid carcinomas, and uterine endometrioid carcinomas, all of which arise from endometrial epithelium. This review will summarize the recent advances in studying the roles of ARID1A mutations in gynecologic cancers with special emphasis on how this new knowledge will further extend our understanding of the pathogenesis of endometrium-related carcinomas. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2013-10 2013-10-02 /pmc/articles/PMC3805919/ /pubmed/24167674 http://dx.doi.org/10.3802/jgo.2013.24.4.376 Text en Copyright © 2013. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mao, Tsui-Lien
Shih, Ie-Ming
The roles of ARID1A in gynecologic cancer
title The roles of ARID1A in gynecologic cancer
title_full The roles of ARID1A in gynecologic cancer
title_fullStr The roles of ARID1A in gynecologic cancer
title_full_unstemmed The roles of ARID1A in gynecologic cancer
title_short The roles of ARID1A in gynecologic cancer
title_sort roles of arid1a in gynecologic cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805919/
https://www.ncbi.nlm.nih.gov/pubmed/24167674
http://dx.doi.org/10.3802/jgo.2013.24.4.376
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