LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development

Epidermal growth factor receptor (EGFR) pathway activation is a frequent event in human carcinomas. Mutations in EGFR itself are, however, rare, and the mechanisms regulating EGFR activation remain elusive. Leucine-rich immunoglobulin repeats-1 (LRIG1), an inhibitor of EGFR activity, is one of four...

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Detalles Bibliográficos
Autores principales: Lu, Liwen, Teixeira, Vitor H, Yuan, ZhengQiang, Graham, Trevor A, Endesfelder, David, Kolluri, Krishna, Al-Juffali, Noura, Hamilton, Nicholas, Nicholson, Andrew G, Falzon, Mary, Kschischo, Maik, Swanton, Charles, Wright, Nicholas A, Carroll, Bernadette, Watt, Fiona M, George, Jeremy P, Jensen, Kim B, Giangreco, Adam, Janes, Sam M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806036/
https://www.ncbi.nlm.nih.gov/pubmed/23208928
http://dx.doi.org/10.1002/path.4148

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