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Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes

The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-à-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through...

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Autores principales: Chan, Gabriel Hoi-huen, Law, Betty Yuen-kwan, Chu, John Man-tak, Yue, Kevin Kin-man, Jiang, Zhi-hong, Lau, Chi-wai, Huang, Yu, Chan, Shun-wan, Ying-kit Yue, Patrick, Wong, Ricky Ngok-shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806155/
https://www.ncbi.nlm.nih.gov/pubmed/24194784
http://dx.doi.org/10.1155/2013/797310
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author Chan, Gabriel Hoi-huen
Law, Betty Yuen-kwan
Chu, John Man-tak
Yue, Kevin Kin-man
Jiang, Zhi-hong
Lau, Chi-wai
Huang, Yu
Chan, Shun-wan
Ying-kit Yue, Patrick
Wong, Ricky Ngok-shun
author_facet Chan, Gabriel Hoi-huen
Law, Betty Yuen-kwan
Chu, John Man-tak
Yue, Kevin Kin-man
Jiang, Zhi-hong
Lau, Chi-wai
Huang, Yu
Chan, Shun-wan
Ying-kit Yue, Patrick
Wong, Ricky Ngok-shun
author_sort Chan, Gabriel Hoi-huen
collection PubMed
description The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-à-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through its antiobesity and anti-inflammation properties. We investigated the vascular protective effects of ginseng by administrating ginseng extracts to rats after the induction of diabetes. We found that Panax ginseng can restore diabetes-induced impaired vasorelaxation and can reduce serum triglyceride but not cholesterol level in the diabetic rats. The ginseng extracts also suppressed the expression of atherosclerosis-related genes and altered the expression of lipid-related genes. The results provide evidence that Panax ginseng improves vascular dysfunction induced by diabetes and the protective effects may possibly be due to the downregulation of atherosclerosis-related genes and altered lipid metabolism, which help to restore normal endothelium functions.
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spelling pubmed-38061552013-11-05 Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes Chan, Gabriel Hoi-huen Law, Betty Yuen-kwan Chu, John Man-tak Yue, Kevin Kin-man Jiang, Zhi-hong Lau, Chi-wai Huang, Yu Chan, Shun-wan Ying-kit Yue, Patrick Wong, Ricky Ngok-shun Evid Based Complement Alternat Med Research Article The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-à-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through its antiobesity and anti-inflammation properties. We investigated the vascular protective effects of ginseng by administrating ginseng extracts to rats after the induction of diabetes. We found that Panax ginseng can restore diabetes-induced impaired vasorelaxation and can reduce serum triglyceride but not cholesterol level in the diabetic rats. The ginseng extracts also suppressed the expression of atherosclerosis-related genes and altered the expression of lipid-related genes. The results provide evidence that Panax ginseng improves vascular dysfunction induced by diabetes and the protective effects may possibly be due to the downregulation of atherosclerosis-related genes and altered lipid metabolism, which help to restore normal endothelium functions. Hindawi Publishing Corporation 2013 2013-09-30 /pmc/articles/PMC3806155/ /pubmed/24194784 http://dx.doi.org/10.1155/2013/797310 Text en Copyright © 2013 Gabriel Hoi-huen Chan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chan, Gabriel Hoi-huen
Law, Betty Yuen-kwan
Chu, John Man-tak
Yue, Kevin Kin-man
Jiang, Zhi-hong
Lau, Chi-wai
Huang, Yu
Chan, Shun-wan
Ying-kit Yue, Patrick
Wong, Ricky Ngok-shun
Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title_full Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title_fullStr Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title_full_unstemmed Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title_short Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
title_sort ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806155/
https://www.ncbi.nlm.nih.gov/pubmed/24194784
http://dx.doi.org/10.1155/2013/797310
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