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Highly Ordered Architecture of MicroRNA Cluster
Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the onc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806224/ https://www.ncbi.nlm.nih.gov/pubmed/24195073 http://dx.doi.org/10.1155/2013/463168 |
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author | Shi, Bing Zhu, Mingxuan Liu, Shuang Zhang, Mandun |
author_facet | Shi, Bing Zhu, Mingxuan Liu, Shuang Zhang, Mandun |
author_sort | Shi, Bing |
collection | PubMed |
description | Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology. |
format | Online Article Text |
id | pubmed-3806224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38062242013-11-05 Highly Ordered Architecture of MicroRNA Cluster Shi, Bing Zhu, Mingxuan Liu, Shuang Zhang, Mandun Biomed Res Int Research Article Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology. Hindawi Publishing Corporation 2013 2013-09-30 /pmc/articles/PMC3806224/ /pubmed/24195073 http://dx.doi.org/10.1155/2013/463168 Text en Copyright © 2013 Bing Shi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shi, Bing Zhu, Mingxuan Liu, Shuang Zhang, Mandun Highly Ordered Architecture of MicroRNA Cluster |
title | Highly Ordered Architecture of MicroRNA Cluster |
title_full | Highly Ordered Architecture of MicroRNA Cluster |
title_fullStr | Highly Ordered Architecture of MicroRNA Cluster |
title_full_unstemmed | Highly Ordered Architecture of MicroRNA Cluster |
title_short | Highly Ordered Architecture of MicroRNA Cluster |
title_sort | highly ordered architecture of microrna cluster |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806224/ https://www.ncbi.nlm.nih.gov/pubmed/24195073 http://dx.doi.org/10.1155/2013/463168 |
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