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Highly Ordered Architecture of MicroRNA Cluster

Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the onc...

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Detalles Bibliográficos
Autores principales: Shi, Bing, Zhu, Mingxuan, Liu, Shuang, Zhang, Mandun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806224/
https://www.ncbi.nlm.nih.gov/pubmed/24195073
http://dx.doi.org/10.1155/2013/463168
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author Shi, Bing
Zhu, Mingxuan
Liu, Shuang
Zhang, Mandun
author_facet Shi, Bing
Zhu, Mingxuan
Liu, Shuang
Zhang, Mandun
author_sort Shi, Bing
collection PubMed
description Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology.
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spelling pubmed-38062242013-11-05 Highly Ordered Architecture of MicroRNA Cluster Shi, Bing Zhu, Mingxuan Liu, Shuang Zhang, Mandun Biomed Res Int Research Article Although it is known that the placement of genes in a cluster may be critical for proper expression patterns, it remains largely unclear whether the orders of members in an miRNA cluster have biological insights. By investigating the relationship between expression and orders for miRNAs from the oncogenic miR-17-92 cluster, we observed a highly ordered architecture in this cluster. A significant correlation between miRNA expression level and its placement was revealed. More importantly, the placement of these miRNAs is associated with their dysregulation in cancer. Here, we presented the opinion that miRNA clusters are not arranged randomly but show highly ordered architectures, which may have critical roles in physiology and pathology. Hindawi Publishing Corporation 2013 2013-09-30 /pmc/articles/PMC3806224/ /pubmed/24195073 http://dx.doi.org/10.1155/2013/463168 Text en Copyright © 2013 Bing Shi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shi, Bing
Zhu, Mingxuan
Liu, Shuang
Zhang, Mandun
Highly Ordered Architecture of MicroRNA Cluster
title Highly Ordered Architecture of MicroRNA Cluster
title_full Highly Ordered Architecture of MicroRNA Cluster
title_fullStr Highly Ordered Architecture of MicroRNA Cluster
title_full_unstemmed Highly Ordered Architecture of MicroRNA Cluster
title_short Highly Ordered Architecture of MicroRNA Cluster
title_sort highly ordered architecture of microrna cluster
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806224/
https://www.ncbi.nlm.nih.gov/pubmed/24195073
http://dx.doi.org/10.1155/2013/463168
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