A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial muco...

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Autores principales: Nishiuma, Teruaki, Ohnishi, Hisashi, Yoshimura, Sho, Kinami, Saori, Sakamoto, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806251/
https://www.ncbi.nlm.nih.gov/pubmed/24198834
http://dx.doi.org/10.1155/2013/208194
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author Nishiuma, Teruaki
Ohnishi, Hisashi
Yoshimura, Sho
Kinami, Saori
Sakamoto, Susumu
author_facet Nishiuma, Teruaki
Ohnishi, Hisashi
Yoshimura, Sho
Kinami, Saori
Sakamoto, Susumu
author_sort Nishiuma, Teruaki
collection PubMed
description A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.
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spelling pubmed-38062512013-11-06 A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa Nishiuma, Teruaki Ohnishi, Hisashi Yoshimura, Sho Kinami, Saori Sakamoto, Susumu Case Rep Med Case Report A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa. Hindawi Publishing Corporation 2013 2013-09-30 /pmc/articles/PMC3806251/ /pubmed/24198834 http://dx.doi.org/10.1155/2013/208194 Text en Copyright © 2013 Teruaki Nishiuma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nishiuma, Teruaki
Ohnishi, Hisashi
Yoshimura, Sho
Kinami, Saori
Sakamoto, Susumu
A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_full A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_fullStr A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_full_unstemmed A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_short A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_sort case of granulomatosis with polyangiitis (wegener's granulomatosis) presenting with marked inflamed tracheobronchial mucosa
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806251/
https://www.ncbi.nlm.nih.gov/pubmed/24198834
http://dx.doi.org/10.1155/2013/208194
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