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Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations

The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein choles...

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Autores principales: Huang, Ping, Yin, Rui-Xing, Huang, Ke-Ke, Zeng, Xiao-Na, Guo, Tao, Lin, Quan-Zhen, Wu, Jian, Wu, Dong-Feng, Li, Hui, Pan, Shang-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806325/
https://www.ncbi.nlm.nih.gov/pubmed/24195066
http://dx.doi.org/10.1155/2013/231515
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author Huang, Ping
Yin, Rui-Xing
Huang, Ke-Ke
Zeng, Xiao-Na
Guo, Tao
Lin, Quan-Zhen
Wu, Jian
Wu, Dong-Feng
Li, Hui
Pan, Shang-Ling
author_facet Huang, Ping
Yin, Rui-Xing
Huang, Ke-Ke
Zeng, Xiao-Na
Guo, Tao
Lin, Quan-Zhen
Wu, Jian
Wu, Dong-Feng
Li, Hui
Pan, Shang-Ling
author_sort Huang, Ping
collection PubMed
description The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P < 0.05). The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P < 0.05) than the T allele noncarriers. Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers. The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype. Serum lipid parameters were also correlated with several environmental factors in both ethnic groups. The differences in the association of KLF14 rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions.
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spelling pubmed-38063252013-11-05 Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations Huang, Ping Yin, Rui-Xing Huang, Ke-Ke Zeng, Xiao-Na Guo, Tao Lin, Quan-Zhen Wu, Jian Wu, Dong-Feng Li, Hui Pan, Shang-Ling Biomed Res Int Research Article The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P < 0.05). The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P < 0.05) than the T allele noncarriers. Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers. The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype. Serum lipid parameters were also correlated with several environmental factors in both ethnic groups. The differences in the association of KLF14 rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions. Hindawi Publishing Corporation 2013 2013-09-30 /pmc/articles/PMC3806325/ /pubmed/24195066 http://dx.doi.org/10.1155/2013/231515 Text en Copyright © 2013 Ping Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Ping
Yin, Rui-Xing
Huang, Ke-Ke
Zeng, Xiao-Na
Guo, Tao
Lin, Quan-Zhen
Wu, Jian
Wu, Dong-Feng
Li, Hui
Pan, Shang-Ling
Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title_full Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title_fullStr Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title_full_unstemmed Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title_short Association of the KLF14 rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations
title_sort association of the klf14 rs4731702 snp and serum lipid levels in the guangxi mulao and han populations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806325/
https://www.ncbi.nlm.nih.gov/pubmed/24195066
http://dx.doi.org/10.1155/2013/231515
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