Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix molecule responsible for vessel compression because...

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Detalles Bibliográficos
Autores principales: Chauhan, Vikash P., Martin, John D., Liu, Hao, Lacorre, Delphine A., Jain, Saloni R., Kozin, Sergey V., Stylianopoulos, Triantafyllos, Mousa, Ahmed S., Han, Xiaoxing, Adstamongkonkul, Pichet, Popović, Zoran, Huang, Peigen, Bawendi, Moungi G., Boucher, Yves, Jain, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806395/
https://www.ncbi.nlm.nih.gov/pubmed/24084631
http://dx.doi.org/10.1038/ncomms3516

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