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Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy

PURPOSE: Determine the incidence of anterior (AZ) and transition (TZ) zone prostate cancers using a transperineal mapping approach. METHODS: A retrospective review of 137 patients with history of previous negative biopsy undergoing transperineal saturation biopsy for an elevated prostate-specific an...

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Autores principales: Danforth, Teresa L, Chevli, K Kent, Baumann, Louis, Duff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806447/
https://www.ncbi.nlm.nih.gov/pubmed/24199184
http://dx.doi.org/10.2147/RRU.S37868
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author Danforth, Teresa L
Chevli, K Kent
Baumann, Louis
Duff, Michael
author_facet Danforth, Teresa L
Chevli, K Kent
Baumann, Louis
Duff, Michael
author_sort Danforth, Teresa L
collection PubMed
description PURPOSE: Determine the incidence of anterior (AZ) and transition (TZ) zone prostate cancers using a transperineal mapping approach. METHODS: A retrospective review of 137 patients with history of previous negative biopsy undergoing transperineal saturation biopsy for an elevated prostate-specific antigen (PSA), high-grade prostate intraepithelial neoplasia, atypical small acinar proliferation history, or abnormal digital rectal exam. The number of biopsy cores was determined by prostate volume and obtained using a predefined template. The electronic medical records were reviewed for patients’ clinical and pathological characteristics. RESULTS: Forty-one of 137 patients (31.4%) had positive biopsy for prostate adenocarcinoma; 11 were from 24-core, 19 from 36-core, and 11 from 48-core sampling. Glands > 45 mL had a mean of 1.7 previous biopsies and a PSA of 9.1 ng/mL. Glands < 30 mL were 1.3 and 6.3 ng/mL and glands 30–45 mL were 1.4 and 6.5 ng/mL. Glands < 45 mL had a higher number of positive biopsies per total cores. Seven patients chose active surveillance while 34 chose treatment. Of the 36- and 48-cores biopsies, 2.2% and 1.5%, respectively, were positive in the TZ. One patient was AZ-positive, 1 was TZ-positive, and 18 were peripheral zone (PZ)-positive alone. Twelve patients had cancer detected in PZ and TZ. Two patients developed urinary retention and one had a urine infection. CONCLUSION: Transperineal saturation biopsy is a safe and efficacious method of prostate cancer detection in patients with previous negative biopsy and high suspicion for cancer. Few cancers were found to originate in the TZ or AZ alone. We recommend that initial biopsy templates should sample PZ with less focus on the TZ.
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spelling pubmed-38064472013-11-06 Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy Danforth, Teresa L Chevli, K Kent Baumann, Louis Duff, Michael Res Rep Urol Original Research PURPOSE: Determine the incidence of anterior (AZ) and transition (TZ) zone prostate cancers using a transperineal mapping approach. METHODS: A retrospective review of 137 patients with history of previous negative biopsy undergoing transperineal saturation biopsy for an elevated prostate-specific antigen (PSA), high-grade prostate intraepithelial neoplasia, atypical small acinar proliferation history, or abnormal digital rectal exam. The number of biopsy cores was determined by prostate volume and obtained using a predefined template. The electronic medical records were reviewed for patients’ clinical and pathological characteristics. RESULTS: Forty-one of 137 patients (31.4%) had positive biopsy for prostate adenocarcinoma; 11 were from 24-core, 19 from 36-core, and 11 from 48-core sampling. Glands > 45 mL had a mean of 1.7 previous biopsies and a PSA of 9.1 ng/mL. Glands < 30 mL were 1.3 and 6.3 ng/mL and glands 30–45 mL were 1.4 and 6.5 ng/mL. Glands < 45 mL had a higher number of positive biopsies per total cores. Seven patients chose active surveillance while 34 chose treatment. Of the 36- and 48-cores biopsies, 2.2% and 1.5%, respectively, were positive in the TZ. One patient was AZ-positive, 1 was TZ-positive, and 18 were peripheral zone (PZ)-positive alone. Twelve patients had cancer detected in PZ and TZ. Two patients developed urinary retention and one had a urine infection. CONCLUSION: Transperineal saturation biopsy is a safe and efficacious method of prostate cancer detection in patients with previous negative biopsy and high suspicion for cancer. Few cancers were found to originate in the TZ or AZ alone. We recommend that initial biopsy templates should sample PZ with less focus on the TZ. Dove Medical Press 2012-12-05 /pmc/articles/PMC3806447/ /pubmed/24199184 http://dx.doi.org/10.2147/RRU.S37868 Text en © 2012 Danforth et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Danforth, Teresa L
Chevli, K Kent
Baumann, Louis
Duff, Michael
Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title_full Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title_fullStr Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title_full_unstemmed Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title_short Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
title_sort low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806447/
https://www.ncbi.nlm.nih.gov/pubmed/24199184
http://dx.doi.org/10.2147/RRU.S37868
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