Cargando…

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzmán, Esther A., Wright, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806460/ https://www.ncbi.nlm.nih.gov/pubmed/24048269 http://dx.doi.org/10.3390/md11093500

Ejemplares similares

Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516
por: Kallifatidis, Georgios, et al.
Publicado: (2014)

The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein
por: Karan, Dev, et al.
Publicado: (2020)

RIP1 Mediates Manzamine-A-Induced Secretory Autophagy in Breast Cancer
por: Wang, Xuan, et al.
Publicado: (2023)

Differential modulation of microglia superoxide anion and thromboxane B(2 )generation by the marine manzamines
por: Mayer, Alejandro MS, et al.
Publicado: (2005)

Manzamine-A Alters In Vitro Calvarial Osteoblast Function
por: Hardy, Samantha, et al.
Publicado: (2022)

The vacuolar-ATPase (V-ATPase) modulates matrix metalloproteinase (MMP) isoforms in human pancreatic cancer
por: Chung, Chuhan, et al.
Publicado: (2011)

Covalent Targeting of the Vacuolar H(+)-ATPase Activates Autophagy Via mTORC1 Inhibition
por: Yik-Sham Chung, Clive, et al.
Publicado: (2019)

Role of the vacuolar ATPase in the Alphavirus replication cycle
por: Schuchman, Ryan M., et al.
Publicado: (2018)

A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival
por: Paha, Jiraporn, et al.
Publicado: (2019)

Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells
por: Lin, Li-Chun, et al.
Publicado: (2018)

Mutations in the Proteolipid Subunits of the Vacuolar H(+)-ATPase Provide Resistance to Indolotryptoline Natural Products
por: Chang, Fang-Yuan, et al.
Publicado: (2014)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

Rotating with the brakes on and other unresolved features of the vacuolar ATPase
por: Rawson, Shaun, et al.
Publicado: (2016)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
por: Ohta, T., et al.
Publicado: (1996)

Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells
por: Park, Yeeun, et al.
Publicado: (2020)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014)

Inhibition of Host Vacuolar H(+)-ATPase Activity by a Legionella pneumophila Effector
por: Xu, Li, et al.
Publicado: (2010)

Cancer with low cathepsin D levels is susceptible to vacuolar (H(+))‐ATPase inhibition
por: Kitazawa, Satoshi, et al.
Publicado: (2017)

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling
por: Kobia, Francis, et al.
Publicado: (2013)

An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45
por: Jansen, Eric J. R., et al.
Publicado: (2009)

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
por: Di Cristofori, Andrea, et al.
Publicado: (2015)

Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016)

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
por: Chang, Ya-Wen, et al.
Publicado: (2021)

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins
Publicado: (1989)

Probing Subunit-Subunit Interactions in the Yeast Vacuolar ATPase by Peptide Arrays
por: Parsons, Lee S., et al.
Publicado: (2012)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle
por: Kim, Sung Woo, et al.
Publicado: (2021)

The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake
por: Alder, Arne, et al.
Publicado: (2023)

The Vacuolar H(+) ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells
por: Flinck, Mette, et al.
Publicado: (2020)

RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study
por: Mayer, Alejandro M. S., et al.
Publicado: (2021)

Reconstitution of Vacuolar-type Rotary H(+)-ATPase/Synthase from Thermus thermophilus
por: Kishikawa, Jun-ichi, et al.
Publicado: (2012)

The Vacuolar-Type H(+)-ATPase in Ovine Rumen Epithelium is Regulated by Metabolic Signals
por: Kuzinski, Judith, et al.
Publicado: (2010)

The d subunit plays a central role in human vacuolar H(+)-ATPases
por: Smith, Annabel N., et al.
Publicado: (2008)

Retrieval of the Vacuolar H(+)-ATPase from Phagosomes Revealed by Live Cell Imaging
por: Clarke, Margaret, et al.
Publicado: (2010)

A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach
por: Lucia, Umberto, et al.
Publicado: (2014)

Structure of the Vacuolar H(+)-ATPase Rotary Motor Reveals New Mechanistic Insights
por: Rawson, Shaun, et al.
Publicado: (2015)

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
por: Whitton, Bradleigh, et al.
Publicado: (2018)

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
por: Farsi, Zohreh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9jktp3n9htdk3ov7v8cdm6lmu0