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Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway
Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9′-fucoxanthinone (APO-9′) isolated from S. muticum on pro-inflammatory cytokine production. S. muticum extract (SME) exhibited signific...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806467/ https://www.ncbi.nlm.nih.gov/pubmed/23985898 http://dx.doi.org/10.3390/md11093272 |
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author | Chae, Doobyeong Manzoor, Zahid Kim, Sung Chun Kim, Sohyun Oh, Tae-Heon Yoo, Eun-Sook Kang, Hee-Kyoung Hyun, Jin-Won Lee, Nam Ho Ko, Mi-Hee Koh, Young-Sang |
author_facet | Chae, Doobyeong Manzoor, Zahid Kim, Sung Chun Kim, Sohyun Oh, Tae-Heon Yoo, Eun-Sook Kang, Hee-Kyoung Hyun, Jin-Won Lee, Nam Ho Ko, Mi-Hee Koh, Young-Sang |
author_sort | Chae, Doobyeong |
collection | PubMed |
description | Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9′-fucoxanthinone (APO-9′) isolated from S. muticum on pro-inflammatory cytokine production. S. muticum extract (SME) exhibited significant inhibitory effects on pro-inflammatory cytokine production in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). APO-9′ pre-treatment in the CpG DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-α production with IC(50) values ranging from 5.31 to 13.79. It exhibited a strong inhibitory effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter activity. APO-9′ pre-treatment exhibited significant inhibition of CpG DNA-induced production of inducible nitric oxide synthase. Taken together, these data suggest that SME and APO-9′ have a significant anti-inflammatory property and warrant further studies concerning the potentials of SME and APO-9′ for medicinal use. |
format | Online Article Text |
id | pubmed-3806467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38064672013-10-23 Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway Chae, Doobyeong Manzoor, Zahid Kim, Sung Chun Kim, Sohyun Oh, Tae-Heon Yoo, Eun-Sook Kang, Hee-Kyoung Hyun, Jin-Won Lee, Nam Ho Ko, Mi-Hee Koh, Young-Sang Mar Drugs Article Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9′-fucoxanthinone (APO-9′) isolated from S. muticum on pro-inflammatory cytokine production. S. muticum extract (SME) exhibited significant inhibitory effects on pro-inflammatory cytokine production in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). APO-9′ pre-treatment in the CpG DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-α production with IC(50) values ranging from 5.31 to 13.79. It exhibited a strong inhibitory effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter activity. APO-9′ pre-treatment exhibited significant inhibition of CpG DNA-induced production of inducible nitric oxide synthase. Taken together, these data suggest that SME and APO-9′ have a significant anti-inflammatory property and warrant further studies concerning the potentials of SME and APO-9′ for medicinal use. MDPI 2013-08-27 /pmc/articles/PMC3806467/ /pubmed/23985898 http://dx.doi.org/10.3390/md11093272 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Chae, Doobyeong Manzoor, Zahid Kim, Sung Chun Kim, Sohyun Oh, Tae-Heon Yoo, Eun-Sook Kang, Hee-Kyoung Hyun, Jin-Won Lee, Nam Ho Ko, Mi-Hee Koh, Young-Sang Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title | Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title_full | Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title_fullStr | Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title_full_unstemmed | Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title_short | Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway |
title_sort | apo-9′-fucoxanthinone, isolated from sargassum muticum, inhibits cpg-induced inflammatory response by attenuating the mitogen-activated protein kinase pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806467/ https://www.ncbi.nlm.nih.gov/pubmed/23985898 http://dx.doi.org/10.3390/md11093272 |
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