Maternal Obesity Induces Epigenetic Modifications to Facilitate Zfp423 Expression and Enhance Adipogenic Differentiation in Fetal Mice

Maternal obesity (MO) predisposes offspring to obesity and type 2 diabetes despite poorly defined mechanisms. Zfp423 is the key transcription factor committing cells to the adipogenic lineage, with exceptionally dense CpG sites in its promoter. We hypothesized that MO enhances adipogenic differentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Qi-Yuan, Liang, Jun-Fang, Rogers, Carl J., Zhao, Jun-Xing, Zhu, Mei-Jun, Du, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806589/
https://www.ncbi.nlm.nih.gov/pubmed/23884886
http://dx.doi.org/10.2337/db13-0433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806589/
https://www.ncbi.nlm.nih.gov/pubmed/23884886
http://dx.doi.org/10.2337/db13-0433

Ejemplares similares