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High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator–Activated Receptor γ Signaling

Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while pharmacologically administered FGF21 can ameliorate hyperglycemia. The pancreatic islet is an FGF21 target, yet the actions of FGF21 in the islet un...

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Detalles Bibliográficos
Autores principales:	So, Wing Yan, Cheng, Qianni, Chen, Lihua, Evans-Molina, Carmella, Xu, Aimin, Lam, Karen S.L., Leung, Po Sing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806592/ https://www.ncbi.nlm.nih.gov/pubmed/23897951 http://dx.doi.org/10.2337/db13-0645

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