VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR, panretinal photocoagulation, is inherently destructive and has significant visual consequences. Therapies targeting vascular...

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Detalles Bibliográficos
Autores principales: Rodrigues, Murilo, Xin, Xiaoban, Jee, Kathleen, Babapoor-Farrokhran, Savalan, Kashiwabuchi, Fabiana, Ma, Tao, Bhutto, Imran, Hassan, Syed Junaid, Daoud, Yassine, Baranano, David, Solomon, Sharon, Lutty, Gerard, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806594/
https://www.ncbi.nlm.nih.gov/pubmed/23884892
http://dx.doi.org/10.2337/db13-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806594/
https://www.ncbi.nlm.nih.gov/pubmed/23884892
http://dx.doi.org/10.2337/db13-0014

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