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Molecular Mechanism of Sulphonylurea Block of K(ATP) Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes

Sulphonylurea drugs are the therapy of choice for treating neonatal diabetes (ND) caused by mutations in the ATP-sensitive K(+) channel (K(ATP) channel). We investigated the interactions between MgATP, MgADP, and the sulphonylurea gliclazide with K(ATP) channels expressed in Xenopus oocytes. In the...

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Detalles Bibliográficos
Autores principales:	Proks, Peter, de Wet, Heidi, Ashcroft, Frances M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806600/ https://www.ncbi.nlm.nih.gov/pubmed/23835339 http://dx.doi.org/10.2337/db13-0531

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