Age-Dependent Labeling and Imaging of Insulin Secretory Granules

Insulin is stored within the secretory granules of pancreatic β-cells, and impairment of its release is the hallmark of type 2 diabetes. Preferential exocytosis of newly synthesized insulin suggests that granule aging is a key factor influencing insulin secretion. Here, we illustrate a technology th...

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Detalles Bibliográficos
Autores principales: Ivanova, Anna, Kalaidzidis, Yannis, Dirkx, Ronald, Sarov, Mihail, Gerlach, Michael, Schroth-Diez, Britta, Müller, Andreas, Liu, Yanmei, Andree, Cordula, Mulligan, Bernard, Münster, Carla, Kurth, Thomas, Bickle, Marc, Speier, Stephan, Anastassiadis, Konstantinos, Solimena, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806613/
https://www.ncbi.nlm.nih.gov/pubmed/23929935
http://dx.doi.org/10.2337/db12-1819

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