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Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice
Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806616/ https://www.ncbi.nlm.nih.gov/pubmed/23919962 http://dx.doi.org/10.2337/db13-0508 |
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author | Blaise, Sébastien Romier, Béatrice Kawecki, Charlotte Ghirardi, Maxime Rabenoelina, Fanja Baud, Stéphanie Duca, Laurent Maurice, Pascal Heinz, Andrea Schmelzer, Christian E.H. Tarpin, Michel Martiny, Laurent Garbar, Christian Dauchez, Manuel Debelle, Laurent Durlach, Vincent |
author_facet | Blaise, Sébastien Romier, Béatrice Kawecki, Charlotte Ghirardi, Maxime Rabenoelina, Fanja Baud, Stéphanie Duca, Laurent Maurice, Pascal Heinz, Andrea Schmelzer, Christian E.H. Tarpin, Michel Martiny, Laurent Garbar, Christian Dauchez, Manuel Debelle, Laurent Durlach, Vincent |
author_sort | Blaise, Sébastien |
collection | PubMed |
description | Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In the current study, we show that elastin-derived peptides (EDPs) may be involved in the development of insulin resistance (IRES) in mice. In chow-fed mice, acute or chronic intravenous injections of EDPs induced hyperglycemic effects associated with glucose uptake reduction and IRES in skeletal muscle, liver, and adipose tissue. Based on in vivo, in vitro, and in silico approaches, we propose that this IRES is due to interaction between the insulin receptor (IR) and the neuraminidase-1 subunit of the elastin receptor complex triggered by EDPs. This interplay was correlated with decreased sialic acid levels on the β-chain of the IR and reduction of IR signaling. In conclusion, this is the first study to demonstrate that EDPs, which mainly accumulate with aging, may be involved in the insidious development of IRES. |
format | Online Article Text |
id | pubmed-3806616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-38066162014-11-01 Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice Blaise, Sébastien Romier, Béatrice Kawecki, Charlotte Ghirardi, Maxime Rabenoelina, Fanja Baud, Stéphanie Duca, Laurent Maurice, Pascal Heinz, Andrea Schmelzer, Christian E.H. Tarpin, Michel Martiny, Laurent Garbar, Christian Dauchez, Manuel Debelle, Laurent Durlach, Vincent Diabetes Original Research Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In the current study, we show that elastin-derived peptides (EDPs) may be involved in the development of insulin resistance (IRES) in mice. In chow-fed mice, acute or chronic intravenous injections of EDPs induced hyperglycemic effects associated with glucose uptake reduction and IRES in skeletal muscle, liver, and adipose tissue. Based on in vivo, in vitro, and in silico approaches, we propose that this IRES is due to interaction between the insulin receptor (IR) and the neuraminidase-1 subunit of the elastin receptor complex triggered by EDPs. This interplay was correlated with decreased sialic acid levels on the β-chain of the IR and reduction of IR signaling. In conclusion, this is the first study to demonstrate that EDPs, which mainly accumulate with aging, may be involved in the insidious development of IRES. American Diabetes Association 2013-11 2013-10-18 /pmc/articles/PMC3806616/ /pubmed/23919962 http://dx.doi.org/10.2337/db13-0508 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Blaise, Sébastien Romier, Béatrice Kawecki, Charlotte Ghirardi, Maxime Rabenoelina, Fanja Baud, Stéphanie Duca, Laurent Maurice, Pascal Heinz, Andrea Schmelzer, Christian E.H. Tarpin, Michel Martiny, Laurent Garbar, Christian Dauchez, Manuel Debelle, Laurent Durlach, Vincent Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title | Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title_full | Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title_fullStr | Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title_full_unstemmed | Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title_short | Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice |
title_sort | elastin-derived peptides are new regulators of insulin resistance development in mice |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806616/ https://www.ncbi.nlm.nih.gov/pubmed/23919962 http://dx.doi.org/10.2337/db13-0508 |
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