Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Oxidative stress and endothelial dysfunction contribute to vascular complication in diabetes. Extracellular superoxide dismutase (SOD3) is one of the key antioxidant enzymes that obtains copper via copper transporter ATP7A. SOD3 is secreted from vascular smooth muscles cells (VSMCs) and anchors at t...

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Detalles Bibliográficos
Autores principales: Sudhahar, Varadarajan, Urao, Norifumi, Oshikawa, Jin, McKinney, Ronald D., Llanos, Roxana M., Mercer, Julian F.B., Ushio-Fukai, Masuko, Fukai, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806617/
https://www.ncbi.nlm.nih.gov/pubmed/23884884
http://dx.doi.org/10.2337/db12-1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806617/
https://www.ncbi.nlm.nih.gov/pubmed/23884884
http://dx.doi.org/10.2337/db12-1228

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