Cargando…

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

Diabetic kidney disease (DKD) remains the most common cause of end-stage kidney disease despite multifactorial intervention. We demonstrated that increased cholesterol in association with downregulation of ATP-binding cassette transporter ABCA1 occurs in normal human podocytes exposed to the sera of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merscher-Gomez, Sandra, Guzman, Johanna, Pedigo, Christopher E., Lehto, Markku, Aguillon-Prada, Robier, Mendez, Armando, Lassenius, Mariann I., Forsblom, Carol, Yoo, TaeHyun, Villarreal, Rodrigo, Maiguel, Dony, Johnson, Kevin, Goldberg, Ronald, Nair, Viji, Randolph, Ann, Kretzler, Matthias, Nelson, Robert G., Burke, George W., Groop, Per-Henrik, Fornoni, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806621/ https://www.ncbi.nlm.nih.gov/pubmed/23835338 http://dx.doi.org/10.2337/db13-0399

Ejemplares similares

Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy
por: Guzman, Johanna, et al.
Publicado: (2014)

Cyclin-dependent kinase 2 protects podocytes from apoptosis
por: Saurus, Pauliina, et al.
Publicado: (2016)

Response to Comment on: Lassenius et al. Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation. Diabetes Care 2011;34:1809–1815
por: Lassenius, Mariann I., et al.
Publicado: (2012)

Endotoxins are associated with visceral fat mass in type 1 diabetes
por: Lassenius, Mariann I., et al.
Publicado: (2016)

Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
por: Ahola, Aila J, et al.
Publicado: (2017)

Podocyte Pathology and Nephropathy – Sphingolipids in Glomerular Diseases
por: Merscher, Sandra, et al.
Publicado: (2014)

Identification of glomerular and podocyte-specific genes and pathways activated by sera of patients with focal segmental glomerulosclerosis
por: Otalora, Lilian, et al.
Publicado: (2019)

Metabolism, Energetics, and Lipid Biology in the Podocyte – Cellular Cholesterol-Mediated Glomerular Injury
por: Merscher, Sandra, et al.
Publicado: (2014)

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway
por: Saurus, P, et al.
Publicado: (2015)

Dynamin-mediated Nephrin Phosphorylation Regulates Glucose-stimulated Insulin Release in Pancreatic Beta Cells
por: Jeon, Jongmin, et al.
Publicado: (2012)

The podocyte: glomerular sentinel at the crossroads of innate and adaptive immunity
por: Burke, George W., et al.
Publicado: (2023)

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation
por: Lassenius, Mariann I., et al.
Publicado: (2011)

Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes
por: Nymark, Mariann, et al.
Publicado: (2009)

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome
por: Ge, Mengyuan, et al.
Publicado: (2023)

New insights into renal lipid dysmetabolism in diabetic kidney disease
por: Mitrofanova, Alla, et al.
Publicado: (2021)

Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function
por: Jules, Joel, et al.
Publicado: (2013)

Nonimmunologic targets of immunosuppressive agents in podocytes
por: Yoo, Tae-Hyun, et al.
Publicado: (2015)

Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status
por: Parente, Erika B., et al.
Publicado: (2020)

Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes
por: Härma, Mari-Anne, et al.
Publicado: (2020)

Bacterial infections in patients with type 1 diabetes: a 14-year follow-up study
por: Simonsen, Johan R, et al.
Publicado: (2015)

Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes
por: Simonsen, Johan Rasmus, et al.
Publicado: (2021)

Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease
por: Mitrofanova, Alla, et al.
Publicado: (2022)

Use of Lipid-Modifying Agents for the Treatment of Glomerular Diseases
por: Ge, Mengyuan, et al.
Publicado: (2021)

ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease
por: Ito, Marie, et al.
Publicado: (2023)

Implications of Sphingolipid Metabolites in Kidney Diseases
por: Mallela, Shamroop kumar, et al.
Publicado: (2022)

The Gut-Kidney Axis: Putative Interconnections Between Gastrointestinal and Renal Disorders
por: Lehto, Markku, et al.
Publicado: (2018)

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals
por: Lassenius, Mariann I, et al.
Publicado: (2014)

The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction
por: Ge, Mengyuan, et al.
Publicado: (2020)

Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS
por: Mitrofanova, Alla, et al.
Publicado: (2020)

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease
por: Ito, Marie, et al.
Publicado: (2022)

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke
por: Leskelä, Jaakko, et al.
Publicado: (2021)

The cross-sectional associations between sense of coherence and diabetic microvascular complications, glycaemic control, and patients' conceptions of type 1 diabetes
por: Ahola, Aila J, et al.
Publicado: (2010)

Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome
por: Kim, Jin-Ju, et al.
Publicado: (2020)

Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion
por: Wasik, Anita A., et al.
Publicado: (2017)

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
por: Blattner, Simone M., et al.
Publicado: (2013)

Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care
por: Korolainen, Minna A., et al.
Publicado: (2019)

A1C Variability Predicts Incident Cardiovascular Events, Microalbuminuria, and Overt Diabetic Nephropathy in Patients With Type 1 Diabetes
por: Wadén, Johan, et al.
Publicado: (2009)

Fear of hypoglycaemia and self-management in type 1 diabetes
por: Ahola, Aila J., et al.
Publicado: (2016)

Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare
por: Korolainen, Minna A., et al.
Publicado: (2020)

Erenumab Decreases Headache-Related Sick Leave Days and Health Care Visits: A Retrospective Real-World Study in Working Patients with Migraine
por: Autio, Henri, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0o11mb9rl3b6b450b5m20h4q45