Hypersensitivity to Etoposide in Case of Metastatic Gestational Choriocarcinoma

Etoposide is commonly used in the treatment of a variety of neoplasms. Hypersensitivity reactions to etoposide are infrequently reported and include hypotension, hypertension, flushing, diaphoresis, chest discomfort, dyspnea, bronchospasm and loss of consciousness. We report the case of a 39-year-ol...

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Detalles Bibliográficos
Autores principales: Lazović, Biljana, Milenković, Vera, Delić, Marina, Mazić, Sanja, Jeremic, Katarina, Hrgović, Zlatko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: September, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806672/
https://www.ncbi.nlm.nih.gov/pubmed/24163666
http://dx.doi.org/10.1159/000353627
Descripción
Sumario:Etoposide is commonly used in the treatment of a variety of neoplasms. Hypersensitivity reactions to etoposide are infrequently reported and include hypotension, hypertension, flushing, diaphoresis, chest discomfort, dyspnea, bronchospasm and loss of consciousness. We report the case of a 39-year-old woman who experienced acute bronchospasm, tachycardia, hypoxia and hypotension. The symptoms resolved within an hour after administration of intravenous fluids, methylprednisolone, diphenhydramine and oxygen. Subsequently, the patient was given etoposide phosphate without incident.

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