Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro

Occurrence of DNA damage in a cell activates the DNA damage response, a survival mechanism that ensures genomics stability. Two key members of the DNA damage response are the tumor suppressor p53, which is the most frequently mutated gene in cancers, and MDC1, which is a central adaptor that recruit...

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Detalles Bibliográficos
Autores principales: Shahar, Or David, Gabizon, Ronen, Feine, Oren, Alhadeff, Raphael, Ganoth, Assaf, Argaman, Liron, Shimshoni, Elee, Friedler, Assaf, Goldberg, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806821/
https://www.ncbi.nlm.nih.gov/pubmed/24194938
http://dx.doi.org/10.1371/journal.pone.0078472

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