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A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance

In hyperthyroidism, many patients had neuromuscular symptoms and clinical weakness correlated with free thyroxine (T4) concentrations. The common clinical symptoms of chronic thyrotoxic myopathy were characterized by progressive weakness in proximal muscles and atrophy. A 55-year old woman was visit...

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Autores principales: Kim, Tae Jung, Lee, Han Sang, Shin, Je-Young, Kim, Dong-Gun, Kim, Sung-Min, Sung, Jung-Joon, Lee, Kwang-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807010/
https://www.ncbi.nlm.nih.gov/pubmed/24167418
http://dx.doi.org/10.5607/en.2013.22.3.232
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author Kim, Tae Jung
Lee, Han Sang
Shin, Je-Young
Kim, Dong-Gun
Kim, Sung-Min
Sung, Jung-Joon
Lee, Kwang-Woo
author_facet Kim, Tae Jung
Lee, Han Sang
Shin, Je-Young
Kim, Dong-Gun
Kim, Sung-Min
Sung, Jung-Joon
Lee, Kwang-Woo
author_sort Kim, Tae Jung
collection PubMed
description In hyperthyroidism, many patients had neuromuscular symptoms and clinical weakness correlated with free thyroxine (T4) concentrations. The common clinical symptoms of chronic thyrotoxic myopathy were characterized by progressive weakness in proximal muscles and atrophy. A 55-year old woman was visited our hospital with two years of progressive weakness of both legs. Physical examination showed diffuse enlargement of the thyroid gland, muscle atrophy and tachycardia. Motor examination showed proximal weakness in both legs. Serum creatine phosphokinase was normal and electromyography showed a myopathic pattern. Serum thyroxine (T4) was greatly increased and serum thyroid stimulating hormone was very low. Muscle biopsy showed mild atrophic change and type 2 fiber predominance. The patient's symptoms were improved during treatment with methimazole. Herein we report a case of thyrotoxic myopathy with extreme type 2 fiber predominance histologically.
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spelling pubmed-38070102013-10-28 A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance Kim, Tae Jung Lee, Han Sang Shin, Je-Young Kim, Dong-Gun Kim, Sung-Min Sung, Jung-Joon Lee, Kwang-Woo Exp Neurobiol Case Report In hyperthyroidism, many patients had neuromuscular symptoms and clinical weakness correlated with free thyroxine (T4) concentrations. The common clinical symptoms of chronic thyrotoxic myopathy were characterized by progressive weakness in proximal muscles and atrophy. A 55-year old woman was visited our hospital with two years of progressive weakness of both legs. Physical examination showed diffuse enlargement of the thyroid gland, muscle atrophy and tachycardia. Motor examination showed proximal weakness in both legs. Serum creatine phosphokinase was normal and electromyography showed a myopathic pattern. Serum thyroxine (T4) was greatly increased and serum thyroid stimulating hormone was very low. Muscle biopsy showed mild atrophic change and type 2 fiber predominance. The patient's symptoms were improved during treatment with methimazole. Herein we report a case of thyrotoxic myopathy with extreme type 2 fiber predominance histologically. The Korean Society for Brain and Neural Science 2013-09 2013-09-30 /pmc/articles/PMC3807010/ /pubmed/24167418 http://dx.doi.org/10.5607/en.2013.22.3.232 Text en Copyright © Experimental Neurobiology 2013. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Tae Jung
Lee, Han Sang
Shin, Je-Young
Kim, Dong-Gun
Kim, Sung-Min
Sung, Jung-Joon
Lee, Kwang-Woo
A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title_full A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title_fullStr A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title_full_unstemmed A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title_short A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
title_sort case of thyrotoxic myopathy with extreme type 2 fiber predominance
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807010/
https://www.ncbi.nlm.nih.gov/pubmed/24167418
http://dx.doi.org/10.5607/en.2013.22.3.232
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