JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

Cancer-associated protein tyrosine kinase (PTK) mutations usually are gain-of-function (GOF) mutations that drive tumor growth and metastasis. We have found 50 JAK1 truncating mutations in 36 of 635 gynecologic tumors in the Total Cancer Care® (TCC®) tumor bank. Among cancer cell lines containing JA...

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Detalles Bibliográficos
Autores principales: Ren, Yuan, Zhang, Yonghong, Liu, Richard Z., Fenstermacher, David A., Wright, Kenneth L., Teer, Jamie K., Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807107/
https://www.ncbi.nlm.nih.gov/pubmed/24154688
http://dx.doi.org/10.1038/srep03042

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