In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

BACKGROUND: Successful delivery of compounds to the brain and retina is a challenge in the development of therapeutic drugs and imaging agents. This challenge arises because internalization of compounds into the brain and retina is restricted by the blood–brain barrier (BBB) and blood-retinal barrie...

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Detalles Bibliográficos
Autores principales: Watanabe, Kohei, Nishimura, Yuhei, Nomoto, Tsuyoshi, Umemoto, Noriko, Zhang, Zi, Zhang, Beibei, Kuroyanagi, Junya, Shimada, Yasuhito, Shintou, Taichi, Okano, Mie, Miyazaki, Takeshi, Imamura, Takeshi, Tanaka, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807752/
https://www.ncbi.nlm.nih.gov/pubmed/22894547
http://dx.doi.org/10.1186/1471-2202-13-101

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