Cargando…
Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats
BACKGROUND: Multiple-organ failure is the main cause of death in diabetes mellitus (DM). Hyperglycemia-induced oxidative stress is responsible for major diabetic complications, including multiple-organ failure. Medicinal plants possessing antioxidant activity may reduce oxidative stress and improve...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807985/ https://www.ncbi.nlm.nih.gov/pubmed/24174814 http://dx.doi.org/10.4103/0974-8490.118767 |
_version_ | 1782288529150181376 |
---|---|
author | Singh, Rambir Bhardwaj, Priyanka Sharma, Poonam |
author_facet | Singh, Rambir Bhardwaj, Priyanka Sharma, Poonam |
author_sort | Singh, Rambir |
collection | PubMed |
description | BACKGROUND: Multiple-organ failure is the main cause of death in diabetes mellitus (DM). Hyperglycemia-induced oxidative stress is responsible for major diabetic complications, including multiple-organ failure. Medicinal plants possessing antioxidant activity may reduce oxidative stress and improve the functions of various organs affected by hyperglycemia. OBJECTIVES: This study was designed to evaluate the antioxidant effect of Aqueous Extract of Cassia sophera (AECS) in streptozotocin (STZ)-induced diabetic Wistar rats. MATERIALS AND METHODS: AECS (200 mg/kg body weight (bw)) and the standard antidiabetic drug glibenclamide (10 mg/kgbw) were administered orally by gavaging for 28 days. RESULTS: Oral administration of AECS inhibited STZ-induced increase in lipid peroxidation (LPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, creatinine and urea in liver of diabetic rats. Significant increase in activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and a reduced level of glutathione (GSH), were observed in the liver, kidney, pancreas and testis on AECS treatment. CONCLUSION: The results demonstrate that AECS is not only useful in controlling blood glucose, but also has antioxidant potential to protect the liver, kidney, pancreas and testis against damage caused by hyperglycemia-induced oxidative stress. |
format | Online Article Text |
id | pubmed-3807985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38079852013-10-30 Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats Singh, Rambir Bhardwaj, Priyanka Sharma, Poonam Pharmacognosy Res Original Article BACKGROUND: Multiple-organ failure is the main cause of death in diabetes mellitus (DM). Hyperglycemia-induced oxidative stress is responsible for major diabetic complications, including multiple-organ failure. Medicinal plants possessing antioxidant activity may reduce oxidative stress and improve the functions of various organs affected by hyperglycemia. OBJECTIVES: This study was designed to evaluate the antioxidant effect of Aqueous Extract of Cassia sophera (AECS) in streptozotocin (STZ)-induced diabetic Wistar rats. MATERIALS AND METHODS: AECS (200 mg/kg body weight (bw)) and the standard antidiabetic drug glibenclamide (10 mg/kgbw) were administered orally by gavaging for 28 days. RESULTS: Oral administration of AECS inhibited STZ-induced increase in lipid peroxidation (LPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, creatinine and urea in liver of diabetic rats. Significant increase in activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and a reduced level of glutathione (GSH), were observed in the liver, kidney, pancreas and testis on AECS treatment. CONCLUSION: The results demonstrate that AECS is not only useful in controlling blood glucose, but also has antioxidant potential to protect the liver, kidney, pancreas and testis against damage caused by hyperglycemia-induced oxidative stress. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3807985/ /pubmed/24174814 http://dx.doi.org/10.4103/0974-8490.118767 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Singh, Rambir Bhardwaj, Priyanka Sharma, Poonam Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title | Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title_full | Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title_fullStr | Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title_full_unstemmed | Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title_short | Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats |
title_sort | antioxidant and toxicological evaluation of cassia sopherain streptozotocin-induced diabetic wistar rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807985/ https://www.ncbi.nlm.nih.gov/pubmed/24174814 http://dx.doi.org/10.4103/0974-8490.118767 |
work_keys_str_mv | AT singhrambir antioxidantandtoxicologicalevaluationofcassiasopherainstreptozotocininduceddiabeticwistarrats AT bhardwajpriyanka antioxidantandtoxicologicalevaluationofcassiasopherainstreptozotocininduceddiabeticwistarrats AT sharmapoonam antioxidantandtoxicologicalevaluationofcassiasopherainstreptozotocininduceddiabeticwistarrats |