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Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

Chronic hepatitis B virus (HBV) infection remains an important global health problem. Stability of the episomal covalently closed circular HBV DNA (cccDNA) is largely responsible for the modest curative efficacy of available therapy. Since licensed anti-HBV drugs have a post-transcriptional mechanis...

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Detalles Bibliográficos
Autores principales:	Bloom, Kristie, Ely, Abdullah, Mussolino, Claudio, Cathomen, Toni, Arbuthnot, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808145/ https://www.ncbi.nlm.nih.gov/pubmed/23883864 http://dx.doi.org/10.1038/mt.2013.170

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