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The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11. Here, we report that R...

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Detalles Bibliográficos
Autores principales:	Sloan, Katherine E., Bohnsack, Markus T., Watkins, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808153/ https://www.ncbi.nlm.nih.gov/pubmed/24120868 http://dx.doi.org/10.1016/j.celrep.2013.08.049

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