Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults

Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like rec...

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Autores principales: Libraty, Daniel H., Zhang, Lei, Woda, Marcia, Acosta, Luz P., Obcena, AnaMae, Brion, Job D., Capeding, Rosario Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808280/
https://www.ncbi.nlm.nih.gov/pubmed/24205068
http://dx.doi.org/10.1371/journal.pone.0078018
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author Libraty, Daniel H.
Zhang, Lei
Woda, Marcia
Acosta, Luz P.
Obcena, AnaMae
Brion, Job D.
Capeding, Rosario Z.
author_facet Libraty, Daniel H.
Zhang, Lei
Woda, Marcia
Acosta, Luz P.
Obcena, AnaMae
Brion, Job D.
Capeding, Rosario Z.
author_sort Libraty, Daniel H.
collection PubMed
description Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-α. Lower TLR-induced production of pro-IL-1β and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.
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spelling pubmed-38082802013-11-07 Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults Libraty, Daniel H. Zhang, Lei Woda, Marcia Acosta, Luz P. Obcena, AnaMae Brion, Job D. Capeding, Rosario Z. PLoS One Research Article Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-α. Lower TLR-induced production of pro-IL-1β and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility. Public Library of Science 2013-10-25 /pmc/articles/PMC3808280/ /pubmed/24205068 http://dx.doi.org/10.1371/journal.pone.0078018 Text en © 2013 Libraty et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Libraty, Daniel H.
Zhang, Lei
Woda, Marcia
Acosta, Luz P.
Obcena, AnaMae
Brion, Job D.
Capeding, Rosario Z.
Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title_full Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title_fullStr Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title_full_unstemmed Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title_short Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults
title_sort toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808280/
https://www.ncbi.nlm.nih.gov/pubmed/24205068
http://dx.doi.org/10.1371/journal.pone.0078018
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