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C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels

Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest. Kv11.1 channels are members of the KCNH subfamily of...

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Detalles Bibliográficos
Autores principales:	Ng, Chai Ann, Ke, Ying, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Vandenberg, Jamie I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808384/ https://www.ncbi.nlm.nih.gov/pubmed/24204727 http://dx.doi.org/10.1371/journal.pone.0077032

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