Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc

Control of cessation of growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due to its growth. In particular, it was proposed that stretching of the tissue leads to an increase in cell proliferation. Using the model system of the Drosophi...

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Autores principales: Schluck, Thomas, Nienhaus, Ulrike, Aegerter-Wilmsen, Tinri, Aegerter, Christof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808387/
https://www.ncbi.nlm.nih.gov/pubmed/24204600
http://dx.doi.org/10.1371/journal.pone.0076171
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author Schluck, Thomas
Nienhaus, Ulrike
Aegerter-Wilmsen, Tinri
Aegerter, Christof M.
author_facet Schluck, Thomas
Nienhaus, Ulrike
Aegerter-Wilmsen, Tinri
Aegerter, Christof M.
author_sort Schluck, Thomas
collection PubMed
description Control of cessation of growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due to its growth. In particular, it was proposed that stretching of the tissue leads to an increase in cell proliferation. Using the model system of the Drosophila wing imaginal disc, we directly stretch the tissue finding a significant increase in cell proliferation, thus confirming this hypothesis. In addition, we characterize the growth over the entire growth period of the wing disc finding a correlation between the apical cell area and cell proliferation rate. PACS numbers: 87.19.lx, 87.18.Nq, 87.80.Ek, 87.17.Ee, 87.85.Xd
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spelling pubmed-38083872013-11-07 Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc Schluck, Thomas Nienhaus, Ulrike Aegerter-Wilmsen, Tinri Aegerter, Christof M. PLoS One Research Article Control of cessation of growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due to its growth. In particular, it was proposed that stretching of the tissue leads to an increase in cell proliferation. Using the model system of the Drosophila wing imaginal disc, we directly stretch the tissue finding a significant increase in cell proliferation, thus confirming this hypothesis. In addition, we characterize the growth over the entire growth period of the wing disc finding a correlation between the apical cell area and cell proliferation rate. PACS numbers: 87.19.lx, 87.18.Nq, 87.80.Ek, 87.17.Ee, 87.85.Xd Public Library of Science 2013-10-25 /pmc/articles/PMC3808387/ /pubmed/24204600 http://dx.doi.org/10.1371/journal.pone.0076171 Text en © 2013 Schluck et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schluck, Thomas
Nienhaus, Ulrike
Aegerter-Wilmsen, Tinri
Aegerter, Christof M.
Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title_full Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title_fullStr Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title_full_unstemmed Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title_short Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc
title_sort mechanical control of organ size in the development of the drosophila wing disc
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808387/
https://www.ncbi.nlm.nih.gov/pubmed/24204600
http://dx.doi.org/10.1371/journal.pone.0076171
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