Eukaryotic Initiation Factor 2α - a Downstream Effector of Mammalian Target of Rapamycin - Modulates DNA Repair and Cancer Response to Treatment

In an effort to circumvent resistance to rapamycin – an mTOR inhibitor - we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy. We found that rapamycin, at nM concentrations, increased phosphorylation of eukaryotic initiation factor (eI...

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Detalles Bibliográficos
Autores principales: Tuval-Kochen, Liron, Paglin, Shoshana, Keshet, Gilmor, Lerenthal, Yaniv, Nakar, Charles, Golani, Tamar, Toren, Amos, Yahalom, Joachim, Pfeffer, Raphael, Lawrence, Yaacov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808413/
https://www.ncbi.nlm.nih.gov/pubmed/24204783
http://dx.doi.org/10.1371/journal.pone.0077260

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