CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging

CD137 is a costimulatory molecule expressed on activated T cells. Its ligand, CD137L, is expressed on the surface of hematopoietic progenitor cells, and upon binding to CD137 induces reverse signaling into hematopoietic progenitor cells promoting their activation, proliferation and myeloid different...

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Detalles Bibliográficos
Autores principales: Tang, Qianqiao, Koh, Liang Kai, Jiang, Dongsheng, Schwarz, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808697/
https://www.ncbi.nlm.nih.gov/pubmed/23945137

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