Cargando…

The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock

Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compr...

Descripción completa

Detalles Bibliográficos
Autores principales: De Pascale, Gennaro, Cutuli, Salvatore Lucio, Pennisi, Mariano Alberto, Antonelli, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808714/
https://www.ncbi.nlm.nih.gov/pubmed/24223476
http://dx.doi.org/10.1155/2013/625803
_version_ 1782288619480809472
author De Pascale, Gennaro
Cutuli, Salvatore Lucio
Pennisi, Mariano Alberto
Antonelli, Massimo
author_facet De Pascale, Gennaro
Cutuli, Salvatore Lucio
Pennisi, Mariano Alberto
Antonelli, Massimo
author_sort De Pascale, Gennaro
collection PubMed
description Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens. Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway. More than 30% of humans harbor mutations in MBL gene (MBL2) resulting in reduced plasmatic levels and activity. Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear. In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes. However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury. Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice.
format Online
Article
Text
id pubmed-3808714
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-38087142013-11-10 The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock De Pascale, Gennaro Cutuli, Salvatore Lucio Pennisi, Mariano Alberto Antonelli, Massimo Mediators Inflamm Review Article Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens. Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway. More than 30% of humans harbor mutations in MBL gene (MBL2) resulting in reduced plasmatic levels and activity. Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear. In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes. However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury. Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice. Hindawi Publishing Corporation 2013 2013-10-02 /pmc/articles/PMC3808714/ /pubmed/24223476 http://dx.doi.org/10.1155/2013/625803 Text en Copyright © 2013 Gennaro De Pascale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
De Pascale, Gennaro
Cutuli, Salvatore Lucio
Pennisi, Mariano Alberto
Antonelli, Massimo
The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title_full The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title_fullStr The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title_full_unstemmed The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title_short The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
title_sort role of mannose-binding lectin in severe sepsis and septic shock
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808714/
https://www.ncbi.nlm.nih.gov/pubmed/24223476
http://dx.doi.org/10.1155/2013/625803
work_keys_str_mv AT depascalegennaro theroleofmannosebindinglectininseveresepsisandsepticshock
AT cutulisalvatorelucio theroleofmannosebindinglectininseveresepsisandsepticshock
AT pennisimarianoalberto theroleofmannosebindinglectininseveresepsisandsepticshock
AT antonellimassimo theroleofmannosebindinglectininseveresepsisandsepticshock
AT depascalegennaro roleofmannosebindinglectininseveresepsisandsepticshock
AT cutulisalvatorelucio roleofmannosebindinglectininseveresepsisandsepticshock
AT pennisimarianoalberto roleofmannosebindinglectininseveresepsisandsepticshock
AT antonellimassimo roleofmannosebindinglectininseveresepsisandsepticshock