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Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats

It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas. In n...

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Autores principales: Laing, Robyn J., Lasiene, Jurate, Olavarria, Jaime F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808717/
https://www.ncbi.nlm.nih.gov/pubmed/24199194
http://dx.doi.org/10.1155/2013/592426
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author Laing, Robyn J.
Lasiene, Jurate
Olavarria, Jaime F.
author_facet Laing, Robyn J.
Lasiene, Jurate
Olavarria, Jaime F.
author_sort Laing, Robyn J.
collection PubMed
description It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas. In nearly all lateral extrastriate areas, the anatomical and physiological representation of the nasotemporal axis of the visual field mirrors the representation of this axis in V1. To determine whether the mediolateral topography of striate-extrastriate projections is preserved in neonatally enucleated rats, we analyzed the patterns of projections resulting from tracer injections placed at different sites along the mediolateral axis of V1. We found that the correlation between the distance from injection sites to the lateral border of V1 and the distance of the labeling patterns in area 18a was strong in controls and much weaker in enucleates. Data from pairs of injections in the same animal revealed that the separation of area 18a projection fields for a given separation of injection sites was more variable in enucleated than in control rats. Our analysis of single and double tracer injections suggests that neonatal bilateral enucleation weakens, but not completely abolishes, the mediolateral topography in area 18a.
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spelling pubmed-38087172013-11-06 Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats Laing, Robyn J. Lasiene, Jurate Olavarria, Jaime F. Biomed Res Int Research Article It is known that retinal input is necessary for the normal development of striate cortex and its corticocortical connections, but there is little information on the role that retinal input plays in the development of retinotopically organized connections between V1 and surrounding visual areas. In nearly all lateral extrastriate areas, the anatomical and physiological representation of the nasotemporal axis of the visual field mirrors the representation of this axis in V1. To determine whether the mediolateral topography of striate-extrastriate projections is preserved in neonatally enucleated rats, we analyzed the patterns of projections resulting from tracer injections placed at different sites along the mediolateral axis of V1. We found that the correlation between the distance from injection sites to the lateral border of V1 and the distance of the labeling patterns in area 18a was strong in controls and much weaker in enucleates. Data from pairs of injections in the same animal revealed that the separation of area 18a projection fields for a given separation of injection sites was more variable in enucleated than in control rats. Our analysis of single and double tracer injections suggests that neonatal bilateral enucleation weakens, but not completely abolishes, the mediolateral topography in area 18a. Hindawi Publishing Corporation 2013 2013-10-03 /pmc/articles/PMC3808717/ /pubmed/24199194 http://dx.doi.org/10.1155/2013/592426 Text en Copyright © 2013 Robyn J. Laing et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Laing, Robyn J.
Lasiene, Jurate
Olavarria, Jaime F.
Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title_full Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title_fullStr Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title_full_unstemmed Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title_short Topography of Striate-Extrastriate Connections in Neonatally Enucleated Rats
title_sort topography of striate-extrastriate connections in neonatally enucleated rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808717/
https://www.ncbi.nlm.nih.gov/pubmed/24199194
http://dx.doi.org/10.1155/2013/592426
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