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Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study
OBJECTIVES: To describe loss to follow-up (LTFU) at all stages of the HIV programme. DESIGN: A retrospective cohort study. SETTING: The HIV clinic at Hospital National Simão Mendes in Bissau, Guinea-Bissau. PARTICIPANTS: A total of 4080 HIV-infected patients. OUTCOME MEASURES: Baseline characteristi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808780/ https://www.ncbi.nlm.nih.gov/pubmed/24163204 http://dx.doi.org/10.1136/bmjopen-2013-003499 |
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author | Hønge, Bo Langhoff Jespersen, Sanne Nordentoft, Pernille Bejer Medina, Candida da Silva, David da Silva, Zacarias José Østergaard, Lars Laursen, Alex Lund Wejse, Christian |
author_facet | Hønge, Bo Langhoff Jespersen, Sanne Nordentoft, Pernille Bejer Medina, Candida da Silva, David da Silva, Zacarias José Østergaard, Lars Laursen, Alex Lund Wejse, Christian |
author_sort | Hønge, Bo Langhoff |
collection | PubMed |
description | OBJECTIVES: To describe loss to follow-up (LTFU) at all stages of the HIV programme. DESIGN: A retrospective cohort study. SETTING: The HIV clinic at Hospital National Simão Mendes in Bissau, Guinea-Bissau. PARTICIPANTS: A total of 4080 HIV-infected patients. OUTCOME MEASURES: Baseline characteristics, percentages and incidence rates of LTFU as well as LTFU risk factors at four different stages: immediately after HIV diagnosis (stage 1), after the first CD4 cell count and before a follow-up consultation (stage 2), after a follow-up consultation for patients not eligible for antiretroviral treatment (ART; stage 3) and LTFU among patients on ART (stage 4). RESULTS: Almost one-third of the patients were lost to the programme before the first consultation where ART initiation is decided; during the 7-year observation period, more than half of the patients had been lost to follow-up (overall incidence rate=51.1 patients lost per 100 person-years). Age below 30 years at inclusion was a risk factor for LTFU at all stages of the HIV programme. The biggest risk factors were body mass index <18.5 kg/m(2) (stage 1), male gender (stage 2), HIV-2 infection (stage 3) and CD4 cell count <200 cells/μL (stage 4). CONCLUSIONS: In this study, LTFU constituted a major problem, and this may apply to other similar ART facilities. More than half of the patients were lost to follow-up shortly after enrolment, possibly implying a high mortality. Thus, retention should be given a high priority. |
format | Online Article Text |
id | pubmed-3808780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38087802013-10-29 Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study Hønge, Bo Langhoff Jespersen, Sanne Nordentoft, Pernille Bejer Medina, Candida da Silva, David da Silva, Zacarias José Østergaard, Lars Laursen, Alex Lund Wejse, Christian BMJ Open Global Health OBJECTIVES: To describe loss to follow-up (LTFU) at all stages of the HIV programme. DESIGN: A retrospective cohort study. SETTING: The HIV clinic at Hospital National Simão Mendes in Bissau, Guinea-Bissau. PARTICIPANTS: A total of 4080 HIV-infected patients. OUTCOME MEASURES: Baseline characteristics, percentages and incidence rates of LTFU as well as LTFU risk factors at four different stages: immediately after HIV diagnosis (stage 1), after the first CD4 cell count and before a follow-up consultation (stage 2), after a follow-up consultation for patients not eligible for antiretroviral treatment (ART; stage 3) and LTFU among patients on ART (stage 4). RESULTS: Almost one-third of the patients were lost to the programme before the first consultation where ART initiation is decided; during the 7-year observation period, more than half of the patients had been lost to follow-up (overall incidence rate=51.1 patients lost per 100 person-years). Age below 30 years at inclusion was a risk factor for LTFU at all stages of the HIV programme. The biggest risk factors were body mass index <18.5 kg/m(2) (stage 1), male gender (stage 2), HIV-2 infection (stage 3) and CD4 cell count <200 cells/μL (stage 4). CONCLUSIONS: In this study, LTFU constituted a major problem, and this may apply to other similar ART facilities. More than half of the patients were lost to follow-up shortly after enrolment, possibly implying a high mortality. Thus, retention should be given a high priority. BMJ Publishing Group 2013-10-25 /pmc/articles/PMC3808780/ /pubmed/24163204 http://dx.doi.org/10.1136/bmjopen-2013-003499 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Global Health Hønge, Bo Langhoff Jespersen, Sanne Nordentoft, Pernille Bejer Medina, Candida da Silva, David da Silva, Zacarias José Østergaard, Lars Laursen, Alex Lund Wejse, Christian Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title | Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title_full | Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title_fullStr | Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title_full_unstemmed | Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title_short | Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study |
title_sort | loss to follow-up occurs at all stages in the diagnostic and follow-up period among hiv-infected patients in guinea-bissau: a 7-year retrospective cohort study |
topic | Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808780/ https://www.ncbi.nlm.nih.gov/pubmed/24163204 http://dx.doi.org/10.1136/bmjopen-2013-003499 |
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