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Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection

Objective: Helicobacter Pylori (H.pylori) is one of the most important causes of dyspepsia and diagnosis can be made by invasive or non-invasive methods. One of the non-invasive methods, H.pylori stool antigen test (HpSA) is simple, fast and relatively inexpensive. According to this view with regard...

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Autores principales: Sharbatdaran, Majid, Kashifard, Mehrdad, Shefaee, Shahriar, Siadati, Sepideh, Jahed, Babak, Asgari, Samaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publicaitons 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809175/
https://www.ncbi.nlm.nih.gov/pubmed/24353510
http://dx.doi.org/10.12669/pjms.291.2865
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author Sharbatdaran, Majid
Kashifard, Mehrdad
Shefaee, Shahriar
Siadati, Sepideh
Jahed, Babak
Asgari, Samaneh
author_facet Sharbatdaran, Majid
Kashifard, Mehrdad
Shefaee, Shahriar
Siadati, Sepideh
Jahed, Babak
Asgari, Samaneh
author_sort Sharbatdaran, Majid
collection PubMed
description Objective: Helicobacter Pylori (H.pylori) is one of the most important causes of dyspepsia and diagnosis can be made by invasive or non-invasive methods. One of the non-invasive methods, H.pylori stool antigen test (HpSA) is simple, fast and relatively inexpensive. According to this view with regard to gastric biopsy as a gold standard the sensitivity, specificity, positive and negative predictive values of this method were calculated. Methodology: Stool samples of 61 patients who underwent upper endoscopy and gastric biopsy due to dyspepsia were evaluated for H. Pylori stool antigen using sandwich ELISA method. Results: From the 61 patients who participated in this study, H.pylori was diagnosed in 38 (62.3%) gastric biopsies, 25(66%) of these had positive HpSA test. Also, of 27 (37.7%) positive HpSA cases, H.pylori was seen in 25 gastric biopsies. For this method, sensitivity of 66% with 93% positive predictive value was calculated. Also, 91% specificity with 62% negative predictive value was estimated. Conclusion: High positive HpSA indicates high risk of H.pylori infection and high specificity shows that the likelihood of false positive is low. Therefore, physicians can trust on this method and start patient`s treatment.
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spelling pubmed-38091752013-12-18 Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection Sharbatdaran, Majid Kashifard, Mehrdad Shefaee, Shahriar Siadati, Sepideh Jahed, Babak Asgari, Samaneh Pak J Med Sci Original Article Objective: Helicobacter Pylori (H.pylori) is one of the most important causes of dyspepsia and diagnosis can be made by invasive or non-invasive methods. One of the non-invasive methods, H.pylori stool antigen test (HpSA) is simple, fast and relatively inexpensive. According to this view with regard to gastric biopsy as a gold standard the sensitivity, specificity, positive and negative predictive values of this method were calculated. Methodology: Stool samples of 61 patients who underwent upper endoscopy and gastric biopsy due to dyspepsia were evaluated for H. Pylori stool antigen using sandwich ELISA method. Results: From the 61 patients who participated in this study, H.pylori was diagnosed in 38 (62.3%) gastric biopsies, 25(66%) of these had positive HpSA test. Also, of 27 (37.7%) positive HpSA cases, H.pylori was seen in 25 gastric biopsies. For this method, sensitivity of 66% with 93% positive predictive value was calculated. Also, 91% specificity with 62% negative predictive value was estimated. Conclusion: High positive HpSA indicates high risk of H.pylori infection and high specificity shows that the likelihood of false positive is low. Therefore, physicians can trust on this method and start patient`s treatment. Professional Medical Publicaitons 2013 /pmc/articles/PMC3809175/ /pubmed/24353510 http://dx.doi.org/10.12669/pjms.291.2865 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sharbatdaran, Majid
Kashifard, Mehrdad
Shefaee, Shahriar
Siadati, Sepideh
Jahed, Babak
Asgari, Samaneh
Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title_full Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title_fullStr Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title_full_unstemmed Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title_short Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection
title_sort comparison of stool antigen test with gastric biopsy for the detection of helicobacter pylori infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809175/
https://www.ncbi.nlm.nih.gov/pubmed/24353510
http://dx.doi.org/10.12669/pjms.291.2865
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