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Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental?
Two sets of monozygotic (MZ) twins with Kawasaki disease (KD) from two different families are reported. Twin set 1, previously healthy 71-day-old MZ twin girls were diagnosed with incomplete KD and pneumonia. The symptoms occurred at the same time in both girls. Both girls had ectasia of right coron...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publicaitons
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809217/ https://www.ncbi.nlm.nih.gov/pubmed/24353547 http://dx.doi.org/10.12669/pjms.291.2713 |
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author | Zhang, Xiaomei Sun, Jinghui Zhai, Shubo Yang, Sirui |
author_facet | Zhang, Xiaomei Sun, Jinghui Zhai, Shubo Yang, Sirui |
author_sort | Zhang, Xiaomei |
collection | PubMed |
description | Two sets of monozygotic (MZ) twins with Kawasaki disease (KD) from two different families are reported. Twin set 1, previously healthy 71-day-old MZ twin girls were diagnosed with incomplete KD and pneumonia. The symptoms occurred at the same time in both girls. Both girls had ectasia of right coronary arteries. In twin set 2, the younger of 18-month-old MZ twin boys was diagnosed with KD and bronchitis. After 53 days, his elder brother was diagnosed with the same disease. The symptoms occurred at different time, but were almost identical. Neither boy displayed coronary artery changes. These findings support the hypothesis that genes susceptible to KD and coronary-artery lesions may exist in families. The different clinical characteristics among MZ twins from different families also suggest diverse and complex nature of KD. |
format | Online Article Text |
id | pubmed-3809217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Professional Medical Publicaitons |
record_format | MEDLINE/PubMed |
spelling | pubmed-38092172013-12-18 Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? Zhang, Xiaomei Sun, Jinghui Zhai, Shubo Yang, Sirui Pak J Med Sci Case Report Two sets of monozygotic (MZ) twins with Kawasaki disease (KD) from two different families are reported. Twin set 1, previously healthy 71-day-old MZ twin girls were diagnosed with incomplete KD and pneumonia. The symptoms occurred at the same time in both girls. Both girls had ectasia of right coronary arteries. In twin set 2, the younger of 18-month-old MZ twin boys was diagnosed with KD and bronchitis. After 53 days, his elder brother was diagnosed with the same disease. The symptoms occurred at different time, but were almost identical. Neither boy displayed coronary artery changes. These findings support the hypothesis that genes susceptible to KD and coronary-artery lesions may exist in families. The different clinical characteristics among MZ twins from different families also suggest diverse and complex nature of KD. Professional Medical Publicaitons 2013 /pmc/articles/PMC3809217/ /pubmed/24353547 http://dx.doi.org/10.12669/pjms.291.2713 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Zhang, Xiaomei Sun, Jinghui Zhai, Shubo Yang, Sirui Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title | Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title_full | Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title_fullStr | Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title_full_unstemmed | Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title_short | Kawasaki disease in two sets of monozygotic twins: Is the etiology genetic or environmental? |
title_sort | kawasaki disease in two sets of monozygotic twins: is the etiology genetic or environmental? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809217/ https://www.ncbi.nlm.nih.gov/pubmed/24353547 http://dx.doi.org/10.12669/pjms.291.2713 |
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