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Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species

Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. M...

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Autores principales: Biglari, Shirin, Hanafiah, Alfizah, Ramli, Ramliza, Mostafizur Rahman, Md., Mohd Nizam Khaithir, Tzar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publicaitons 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809237/
https://www.ncbi.nlm.nih.gov/pubmed/24353558
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author Biglari, Shirin
Hanafiah, Alfizah
Ramli, Ramliza
Mostafizur Rahman, Md.
Mohd Nizam Khaithir, Tzar
author_facet Biglari, Shirin
Hanafiah, Alfizah
Ramli, Ramliza
Mostafizur Rahman, Md.
Mohd Nizam Khaithir, Tzar
author_sort Biglari, Shirin
collection PubMed
description Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70% to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution.
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spelling pubmed-38092372013-12-18 Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species Biglari, Shirin Hanafiah, Alfizah Ramli, Ramliza Mostafizur Rahman, Md. Mohd Nizam Khaithir, Tzar Pak J Med Sci Original Article Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70% to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution. Professional Medical Publicaitons 2013-04 /pmc/articles/PMC3809237/ /pubmed/24353558 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Biglari, Shirin
Hanafiah, Alfizah
Ramli, Ramliza
Mostafizur Rahman, Md.
Mohd Nizam Khaithir, Tzar
Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title_full Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title_fullStr Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title_full_unstemmed Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title_short Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species
title_sort clinico-epidemiological nature and antibiotic susceptibility profile of acinetobacter species
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809237/
https://www.ncbi.nlm.nih.gov/pubmed/24353558
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