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Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis

Objective: Evaluation of anti-inflammatory effect of Glucosamine sulfate (GS) versus diclofenac sodium (DS) in effusion of osteoarthritic knees. Methodology: In this study, patients were included in this study from 2007-2010 based on American College of Rheumatology criteria with OA and physical exa...

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Autores principales: Korkmaz, Murat, Karaaslan, Fatih, Erdogan, Yalcin, Bolat, Esef, Karacavus, Seyhan, Kizilkaya, Hafize, Gunaydin, Ilhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publicaitons 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809302/
https://www.ncbi.nlm.nih.gov/pubmed/24353641
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author Korkmaz, Murat
Karaaslan, Fatih
Erdogan, Yalcin
Bolat, Esef
Karacavus, Seyhan
Kizilkaya, Hafize
Gunaydin, Ilhan
author_facet Korkmaz, Murat
Karaaslan, Fatih
Erdogan, Yalcin
Bolat, Esef
Karacavus, Seyhan
Kizilkaya, Hafize
Gunaydin, Ilhan
author_sort Korkmaz, Murat
collection PubMed
description Objective: Evaluation of anti-inflammatory effect of Glucosamine sulfate (GS) versus diclofenac sodium (DS) in effusion of osteoarthritic knees. Methodology: In this study, patients were included in this study from 2007-2010 based on American College of Rheumatology criteria with OA and physical examination in effusion of osteoarthritic knees. The patients were divided into two groups. First group (27 patients) DS was given in doses 75 mg twice daily for ten day. In the group II (25 patients) GS was used in doses of 1500 mg two times daily over the first 12 weeks of the study. A closed aspiration was performed. The knee circumference was measured in patients before and 12 week after treatment. Before and after 12 weeks of treatments, both groups of patients were assessed according to the WOMAC questionnaire of knee pain and function scores. Results: Comparison of knee mean circumference between the two groups was not statistically significant before treatment (p=0.938), but significant after treatment (p<0.001). At the end of the 12 week, there was 66.6% complete resolution of effusion in the DS group (18 patients) and 24.0% (6 patients) in the GS group, this was statistically significant (P<0.001). DS groups, results of the beginning and at the end of 12 week measurement showed significant differences in WOMAC pain mean score (P < 0.001) but GS groups not statistically significant (P=0.160). The WOMAC function mean scores in pre and post-treatment periods of follow-up showed significant variation between the two groups (P< 0.001, P<0.001). Conclusions: Our observations suggest that GS is not able to suppress the progression of adjuvant arthritis in OA with effusion of knee osteoarthritis. GS should not be expected as anti-inflammatory influence as DF in the treatment of OA-related effusion.
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spelling pubmed-38093022013-12-18 Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis Korkmaz, Murat Karaaslan, Fatih Erdogan, Yalcin Bolat, Esef Karacavus, Seyhan Kizilkaya, Hafize Gunaydin, Ilhan Pak J Med Sci Original Article Objective: Evaluation of anti-inflammatory effect of Glucosamine sulfate (GS) versus diclofenac sodium (DS) in effusion of osteoarthritic knees. Methodology: In this study, patients were included in this study from 2007-2010 based on American College of Rheumatology criteria with OA and physical examination in effusion of osteoarthritic knees. The patients were divided into two groups. First group (27 patients) DS was given in doses 75 mg twice daily for ten day. In the group II (25 patients) GS was used in doses of 1500 mg two times daily over the first 12 weeks of the study. A closed aspiration was performed. The knee circumference was measured in patients before and 12 week after treatment. Before and after 12 weeks of treatments, both groups of patients were assessed according to the WOMAC questionnaire of knee pain and function scores. Results: Comparison of knee mean circumference between the two groups was not statistically significant before treatment (p=0.938), but significant after treatment (p<0.001). At the end of the 12 week, there was 66.6% complete resolution of effusion in the DS group (18 patients) and 24.0% (6 patients) in the GS group, this was statistically significant (P<0.001). DS groups, results of the beginning and at the end of 12 week measurement showed significant differences in WOMAC pain mean score (P < 0.001) but GS groups not statistically significant (P=0.160). The WOMAC function mean scores in pre and post-treatment periods of follow-up showed significant variation between the two groups (P< 0.001, P<0.001). Conclusions: Our observations suggest that GS is not able to suppress the progression of adjuvant arthritis in OA with effusion of knee osteoarthritis. GS should not be expected as anti-inflammatory influence as DF in the treatment of OA-related effusion. Professional Medical Publicaitons 2013 /pmc/articles/PMC3809302/ /pubmed/24353641 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Korkmaz, Murat
Karaaslan, Fatih
Erdogan, Yalcin
Bolat, Esef
Karacavus, Seyhan
Kizilkaya, Hafize
Gunaydin, Ilhan
Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title_full Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title_fullStr Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title_full_unstemmed Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title_short Efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
title_sort efficacy of treatment with glucosamine sulfate in patients with knee effusion due to osteoarthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809302/
https://www.ncbi.nlm.nih.gov/pubmed/24353641
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