Development of Stability-Indicating Methods for Cefquinome Sulphate

The degradation behavior of cefquinome sulphate in alkaline medium at different temperatures was investigated using both first derivative spectrophotometric and HPLC methods. The drug degradation was found to be pH and temperature dependant. The pH-rate profile indicated a first order dependence of...

Descripción completa

Detalles Bibliográficos
Autores principales: Shantier, Shaza W., Gadkariem, Elrasheed A., Adam, Mohamed O., Mohamed, Magdi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809348/
https://www.ncbi.nlm.nih.gov/pubmed/24170991
_version_ 1782288688398467072
author Shantier, Shaza W.
Gadkariem, Elrasheed A.
Adam, Mohamed O.
Mohamed, Magdi A.
author_facet Shantier, Shaza W.
Gadkariem, Elrasheed A.
Adam, Mohamed O.
Mohamed, Magdi A.
author_sort Shantier, Shaza W.
collection PubMed
description The degradation behavior of cefquinome sulphate in alkaline medium at different temperatures was investigated using both first derivative spectrophotometric and HPLC methods. The drug degradation was found to be pH and temperature dependant. The pH-rate profile indicated a first order dependence of K(obs) on [OH(-)] at pHs ranging between 9 and 11. Arrhenius plot obtained at pH 10 was linear between 65° and 100°C. The estimated activation energy of the hydrolysis was found to be 21.1 kcal mol(-1). Stability-indicating thin-layer chromatographic method for the separation of the drug and its alkaline hydrolysis product has been developed.
format Online
Article
Text
id pubmed-3809348
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Master Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-38093482013-10-29 Development of Stability-Indicating Methods for Cefquinome Sulphate Shantier, Shaza W. Gadkariem, Elrasheed A. Adam, Mohamed O. Mohamed, Magdi A. Int J Biomed Sci Original Article The degradation behavior of cefquinome sulphate in alkaline medium at different temperatures was investigated using both first derivative spectrophotometric and HPLC methods. The drug degradation was found to be pH and temperature dependant. The pH-rate profile indicated a first order dependence of K(obs) on [OH(-)] at pHs ranging between 9 and 11. Arrhenius plot obtained at pH 10 was linear between 65° and 100°C. The estimated activation energy of the hydrolysis was found to be 21.1 kcal mol(-1). Stability-indicating thin-layer chromatographic method for the separation of the drug and its alkaline hydrolysis product has been developed. Master Publishing Group 2013-09 /pmc/articles/PMC3809348/ /pubmed/24170991 Text en © Shaza W. Shantier et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Shantier, Shaza W.
Gadkariem, Elrasheed A.
Adam, Mohamed O.
Mohamed, Magdi A.
Development of Stability-Indicating Methods for Cefquinome Sulphate
title Development of Stability-Indicating Methods for Cefquinome Sulphate
title_full Development of Stability-Indicating Methods for Cefquinome Sulphate
title_fullStr Development of Stability-Indicating Methods for Cefquinome Sulphate
title_full_unstemmed Development of Stability-Indicating Methods for Cefquinome Sulphate
title_short Development of Stability-Indicating Methods for Cefquinome Sulphate
title_sort development of stability-indicating methods for cefquinome sulphate
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809348/
https://www.ncbi.nlm.nih.gov/pubmed/24170991
work_keys_str_mv AT shantiershazaw developmentofstabilityindicatingmethodsforcefquinomesulphate
AT gadkariemelrasheeda developmentofstabilityindicatingmethodsforcefquinomesulphate
AT adammohamedo developmentofstabilityindicatingmethodsforcefquinomesulphate
AT mohamedmagdia developmentofstabilityindicatingmethodsforcefquinomesulphate

Ejemplares similares