Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution, yet direct quantification of double-strand breaks (DSBs) has been limited. Predominant sources of spontaneous DSBs remain elusive. We report synthetic technology for quantifying DSBs using fluorescent-protein fusions of...

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Detalles Bibliográficos
Autores principales: Shee, Chandan, Cox, Ben D, Gu, Franklin, Luengas, Elizabeth M, Joshi, Mohan C, Chiu, Li-Ya, Magnan, David, Halliday, Jennifer A, Frisch, Ryan L, Gibson, Janet L, Nehring, Ralf Bernd, Do, Huong G, Hernandez, Marcos, Li, Lei, Herman, Christophe, Hastings, PJ, Bates, David, Harris, Reuben S, Miller, Kyle M, Rosenberg, Susan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809393/
https://www.ncbi.nlm.nih.gov/pubmed/24171103
http://dx.doi.org/10.7554/eLife.01222

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