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Global association of air pollution and heart failure: a systematic review and meta-analysis

BACKGROUND: Acute exposure to air pollution has been linked to myocardial infarction, but its effect on heart failure is uncertain. We did a systematic review and meta-analysis to assess the association between air pollution and acute decompensated heart failure including hospitalisation and heart f...

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Autores principales: Shah, Anoop SV, Langrish, Jeremy P, Nair, Harish, McAllister, David A, Hunter, Amanda L, Donaldson, Ken, Newby, David E, Mills, Nicholas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lancet Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809511/
https://www.ncbi.nlm.nih.gov/pubmed/23849322
http://dx.doi.org/10.1016/S0140-6736(13)60898-3
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author Shah, Anoop SV
Langrish, Jeremy P
Nair, Harish
McAllister, David A
Hunter, Amanda L
Donaldson, Ken
Newby, David E
Mills, Nicholas L
author_facet Shah, Anoop SV
Langrish, Jeremy P
Nair, Harish
McAllister, David A
Hunter, Amanda L
Donaldson, Ken
Newby, David E
Mills, Nicholas L
author_sort Shah, Anoop SV
collection PubMed
description BACKGROUND: Acute exposure to air pollution has been linked to myocardial infarction, but its effect on heart failure is uncertain. We did a systematic review and meta-analysis to assess the association between air pollution and acute decompensated heart failure including hospitalisation and heart failure mortality. METHODS: Five databases were searched for studies investigating the association between daily increases in gaseous (carbon monoxide, sulphur dioxide, nitrogen dioxide, ozone) and particulate (diameter <2·5 μm [PM(2·5)] or <10 μm [PM(10)]) air pollutants, and heart failure hospitalisations or heart failure mortality. We used a random-effects model to derive overall risk estimates per pollutant. FINDINGS: Of 1146 identified articles, 195 were reviewed in-depth with 35 satisfying inclusion criteria. Heart failure hospitalisation or death was associated with increases in carbon monoxide (3·52% per 1 part per million; 95% CI 2·52–4·54), sulphur dioxide (2·36% per 10 parts per billion; 1·35–3·38), and nitrogen dioxide (1·70% per 10 parts per billion; 1·25–2·16), but not ozone (0·46% per 10 parts per billion; −0·10 to 1·02) concentrations. Increases in particulate matter concentration were associated with heart failure hospitalisation or death (PM(2·5) 2·12% per 10 μg/m(3), 95% CI 1·42–2·82; PM(10) 1·63% per 10 μg/m(3), 95% CI 1·20–2·07). Strongest associations were seen on the day of exposure, with more persistent effects for PM(2·5). In the USA, we estimate that a mean reduction in PM(2·5) of 3·9 μg/m(3) would prevent 7978 heart failure hospitalisations and save a third of a billion US dollars a year. INTERPRETATION: Air pollution has a close temporal association with heart failure hospitalisation and heart failure mortality. Although more studies from developing nations are required, air pollution is a pervasive public health issue with major cardiovascular and health economic consequences, and it should remain a key target for global health policy. FUNDING: British Heart Foundation.
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spelling pubmed-38095112013-10-28 Global association of air pollution and heart failure: a systematic review and meta-analysis Shah, Anoop SV Langrish, Jeremy P Nair, Harish McAllister, David A Hunter, Amanda L Donaldson, Ken Newby, David E Mills, Nicholas L Lancet Articles BACKGROUND: Acute exposure to air pollution has been linked to myocardial infarction, but its effect on heart failure is uncertain. We did a systematic review and meta-analysis to assess the association between air pollution and acute decompensated heart failure including hospitalisation and heart failure mortality. METHODS: Five databases were searched for studies investigating the association between daily increases in gaseous (carbon monoxide, sulphur dioxide, nitrogen dioxide, ozone) and particulate (diameter <2·5 μm [PM(2·5)] or <10 μm [PM(10)]) air pollutants, and heart failure hospitalisations or heart failure mortality. We used a random-effects model to derive overall risk estimates per pollutant. FINDINGS: Of 1146 identified articles, 195 were reviewed in-depth with 35 satisfying inclusion criteria. Heart failure hospitalisation or death was associated with increases in carbon monoxide (3·52% per 1 part per million; 95% CI 2·52–4·54), sulphur dioxide (2·36% per 10 parts per billion; 1·35–3·38), and nitrogen dioxide (1·70% per 10 parts per billion; 1·25–2·16), but not ozone (0·46% per 10 parts per billion; −0·10 to 1·02) concentrations. Increases in particulate matter concentration were associated with heart failure hospitalisation or death (PM(2·5) 2·12% per 10 μg/m(3), 95% CI 1·42–2·82; PM(10) 1·63% per 10 μg/m(3), 95% CI 1·20–2·07). Strongest associations were seen on the day of exposure, with more persistent effects for PM(2·5). In the USA, we estimate that a mean reduction in PM(2·5) of 3·9 μg/m(3) would prevent 7978 heart failure hospitalisations and save a third of a billion US dollars a year. INTERPRETATION: Air pollution has a close temporal association with heart failure hospitalisation and heart failure mortality. Although more studies from developing nations are required, air pollution is a pervasive public health issue with major cardiovascular and health economic consequences, and it should remain a key target for global health policy. FUNDING: British Heart Foundation. Lancet Publishing Group 2013-09-21 /pmc/articles/PMC3809511/ /pubmed/23849322 http://dx.doi.org/10.1016/S0140-6736(13)60898-3 Text en © 2013 Elsevier Ltd. All rights reserved. This document may be redistributed and reused, subject to certain conditions (http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0) .
spellingShingle Articles
Shah, Anoop SV
Langrish, Jeremy P
Nair, Harish
McAllister, David A
Hunter, Amanda L
Donaldson, Ken
Newby, David E
Mills, Nicholas L
Global association of air pollution and heart failure: a systematic review and meta-analysis
title Global association of air pollution and heart failure: a systematic review and meta-analysis
title_full Global association of air pollution and heart failure: a systematic review and meta-analysis
title_fullStr Global association of air pollution and heart failure: a systematic review and meta-analysis
title_full_unstemmed Global association of air pollution and heart failure: a systematic review and meta-analysis
title_short Global association of air pollution and heart failure: a systematic review and meta-analysis
title_sort global association of air pollution and heart failure: a systematic review and meta-analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809511/
https://www.ncbi.nlm.nih.gov/pubmed/23849322
http://dx.doi.org/10.1016/S0140-6736(13)60898-3
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