Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues()

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved b...

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Detalles Bibliográficos
Autores principales: Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809513/
https://www.ncbi.nlm.nih.gov/pubmed/24035097
http://dx.doi.org/10.1016/j.bmcl.2013.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809513/
https://www.ncbi.nlm.nih.gov/pubmed/24035097
http://dx.doi.org/10.1016/j.bmcl.2013.08.010

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